Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

Ardais, Ana Paula; Rocha, Andréia Silva da; Borges, Mauricio; Fioreze, Gabriela T.; Sallaberry, Cássia; Mioranzza, Sabrina; Nunes, Fernanda Costa; Pagnussat, Natália; Botton, Paulo Henrique S.; Cunha, Rodrigo A.; Porciúncula, Lisiane de Oliveira

doi:10.1016/j.bbr.2016.01.026

Cited by 22 publications

(8 citation statements)

References 51 publications

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“…Caffeine administration in naïve rats, during adulthood, counteracted the negative effect exerted by its intake in early life by increasing the protein levels of mBDNF [ 38 ]. Differently, administration of caffeine (1.0 g/L in drinking water) two weeks before mating, during pregnancy, and up to embryonic days 18–20 (E18 or E20) caused a decrease in BDNF protein levels in the whole cortex until E18, while an increase was found at E20 [ 39 ].…”

Section: Coffea Arabica Lmentioning

confidence: 99%

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

et al. 2017

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The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.

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Section: Coffea Arabica Lmentioning

confidence: 99%

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

et al. 2017

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“…However, chronic exposure to CFE (1/3 mg/mL) during pre-adolescence and adolescence were found to alter the learning and memory capacities in male C57BL/6J mice (Poole et al, 2016). In a study, during a brain development stage, CFE (0.3 and 1.0 g/L) produced an impaired memory function in female rats (Ardais et al, 2016). On the other hand, a number of studies performed with CFE, suggesting it has some toxic effects on cardio vascular system (CVS).…”

Section: Recent Literature Evidencesmentioning

confidence: 96%

Underlying side effects of caffeine

Islam¹

2016

IJPSR

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The popular drink, coffee is in great attention due to its promising pharmacological effects. Caffeine (CFE), the known coffee constituent is mainly known for its prominent psychoactive effect on the central nervous system. It has antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, neuro-, lung-, cardiac-, hepato-, reproductive system protective, antidiabetic, anticancer, bone formation and so forth important biological effects. However, CFE is evident to produce a number of side effects in human and other animals. This writing aims at sketching a current underlying toxicological scenario of CFE in human and other animals. Findings suggest that CFE's toxicological impacts are plugged in its dose as well as age, sex, and pathophysiology of the patients. More precautions are needed during pregnancy, those who are planning to be pregnant, lactating women, children, and adolescents, patients with hepatic and cardiovascular complications. Additionally, CFE has toxicological effects on the reproductive system and birth weight. In conclusion, more researches are appreciated to set safe dosages of CFE in groups of consumer.

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“…Though the outcomes of previous studies lack agreement in their overall findings, the data suggest the adenosine system during development is a highly complex modulatory system that varies depending on sex. It has been shown, for example, that caffeine exposure from conception to weaning worsened object recognition memory in female rats, but not male rats, when tested during adulthood (Ardais et al 2016). Conversely, the same exposures to caffeine during development increased locomotor activity in adult male rats, but not female rats, when tested during adulthood (Ardais et al 2016).…”

Section: Sex Differencesmentioning

confidence: 99%

“…It has been shown, for example, that caffeine exposure from conception to weaning worsened object recognition memory in female rats, but not male rats, when tested during adulthood (Ardais et al 2016). Conversely, the same exposures to caffeine during development increased locomotor activity in adult male rats, but not female rats, when tested during adulthood (Ardais et al 2016). Additionally, studies have revealed sex differences in responses to an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats, increasing the motivation for cocaine in females, but not males (Doyle et al 2012).…”

Section: Sex Differencesmentioning

confidence: 99%

Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems

et al. 2019

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Caffeine is the most commonly used drug in the world. However, animal studies suggest that chronic consumption of caffeine during adolescence can result in enhanced anxiety-like behavioral responses during adulthood. One mechanism through which chronic caffeine administration may influence subsequent anxietylike responses is through actions on brainstem serotonergic systems. In order to explore potential effects of chronic caffeine consumption on brainstem serotonergic systems, we evaluated the effects of a 28-day exposure to chronic caffeine (0.3 g/L; postnatal day 28-56) or vehicle administration in the drinking water, followed by 24 h caffeine withdrawal, and subsequent challenge with caffeine (30 mg/kg; s.c.) or vehicle in adolescent male rats. In Experiment 1, acute caffeine challenge induced a widespread activation of serotonergic neurons throughout the dorsal raphe nucleus (DR); this effect was attenuated in rats that had been exposed to chronic caffeine consumption. In Experiment 2, acute caffeine administration profoundly *

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Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

Cited by 22 publications

References 51 publications

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Underlying side effects of caffeine

Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems

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