Caffeine Increases Hippocampal Sharp Waves &lt;i&gt;in Vitro&lt;/i&gt;

Watanabe, Yusuke; Ikegaya, Yuji

doi:10.1248/bpb.b17-00101

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Besides an impact on brain lesions (see below), improved cognition we observed might primarily relate to the ability of caffeine to act on synaptic plasticity. Indeed, in rodents, caffeine treatment on hippocampal slices enhances basal synaptic transmission, long-term potentiation (LTP) and sharp wave–ripple complexes, which underlie memory consolidation [47–50]. Caffeine also controls neuronal excitability and LTP-like effects in the human cortex [51,52].…”

Section: Discussionmentioning

confidence: 99%

Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study

Blum,

Cailliau,

Béhal

et al. 2024

Preprint

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We investigated the link between habitual caffeine intake with memory deficits and CSF AD biomarkers in Mild cognitive impairment (MCI) and Alzheimer s Disease (AD) patients. MCI (N=147) and AD (N=116) patients of the BALTAZAR longitudinal cohort reported their caffeine intake using a dedicated survey and were followed-up for 3 years. Associations of caffeine consumption with cognition, MMSE decline and CSF biomarkers (Tau, pTau181, Ab1-42, Ab1-40) were analyzed using logistic and ANCOVA models. Adjusted on APOE4, age, sex, education level and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95%CI: 1.13 to 5.46]; p=0.023) and lower CSF Ab1-42 (p=0.047), Ab1-42/ A1-40 (p=0.040) and Ab1-42/pTau (p=0.020) in the whole cohort and a faster MMSE decline in amnestic MCI (p=0.024). Data supports the beneficial effect of caffeine consumption to memory decline and CSF amyloid markers in MCI and AD patients.

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Section: Discussionmentioning

confidence: 99%

Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study

Blum,

Cailliau,

Béhal

et al. 2024

Preprint

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“…It is possible that low-frequency components, which are difficult to express in 37 ms, may not be treated by our CNN. In fact, ripples (150-250 Hz) often overlap with sharp waves (5-50 Hz;O'Keefe, 1976;Buzsaki, 2015;Watanabe, 2017) and gamma waves (25-75 Hz;Ramirez-Villegas et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Semisupervised definition of hippocampal ripples

Watanabe

Okada

Ikegaya

2020

Preprint

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Hippocampal ripples are transient neuronal features observed in high-frequency oscillatory bands of local field potentials, and they occur primarily during periods of behavioral immobility and slow-wave sleep. Ripples have been defined based on mathematically engineered features, such as magnitudes, durations, and cycles per event. However, the "ripples" could vary from laboratory to laboratory because their definition is subject to human bias, including the arbitrary choice of parameters and thresholds. In addition, local field potentials are often influenced by myoelectric noise arising from animal movement, making it difficult to distinguish ripples from high-frequency noises. To overcome these problems, we extracted ripple candidates under few constraints and labeled them as binary or stochastic "true" or "false" ripples using Gaussian mixed model clustering and a deep convolutional neural network in a weakly supervised fashion. Our automatic method separated ripples and myoelectric noise and was able to detect ripples even when the animals were moving. Moreover, we confirmed that a convolutional neural network was able to detect ripples defined by our method. Leave-one-animal-out cross-validation estimated the area under the precision-recall curve for ripple detection to be 0.72. Finally, our model establishes an appropriate threshold for the ripple magnitude in the case of the conventional detection of ripples.

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“…The method of hippocampal slice preparation was the same as followed in a previous study [ 78 , 79 ]. After anesthesia, the mice were sacrificed by decapitation, and the entire brain was removed.…”

Section: Methodsmentioning

confidence: 99%

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression

Maki

Sawahata

Akutsu

et al. 2022

IJMS

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that requires further pathological elucidation to establish effective treatment strategies. We previously showed that amyloid β (Aβ) toxic conformer with a turn at positions 22–23 is essential for forming highly toxic oligomers. In the present study, we evaluated phenotypic changes with aging in AD model AppNL-P-F/NL-P-F (NL-P-F) mice with Swedish mutation (NL), Iberian mutation (F), and mutation (P) overproducing E22P-Aβ, a mimic of toxic conformer utilizing the knock-in technique. Furthermore, the role of the toxic conformer in AD pathology was investigated. NL-P-F mice produced soluble toxic conformers from an early age. They showed impaired synaptic plasticity, glial cell activation, and cognitive decline, followed by the accumulation of Aβ plaques and tau hyperphosphorylation. In addition, the protein expression of hypoxia-inducible factor (HIF)-1α was increased, and gene expression of HIF-3α was decreased in NL-P-F mice. HIF dysregulation due to the production of soluble toxic conformers may be involved in AD pathology in NL-P-F mice. This study could reveal the role of a highly toxic Aβ on AD pathogenesis, thereby contributing to the development of a novel therapeutic strategy targeting the toxic conformer.

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Caffeine Increases Hippocampal Sharp Waves <i>in Vitro</i>

Cited by 7 publications

References 25 publications

Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study

Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study

Semisupervised definition of hippocampal ripples

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression

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