Caffeine inhibition of postreplication repair of UV-damaged DNA in mouse epidermal cells

Bowden, G. Tim; Fusenig, N. E.

doi:10.1016/0009-2797(80)90047-2

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…There were several mechanisms for the cancer preventative effects of caffeine against MM. Animal studies have suggested that caffeine inhibits the UVB-induced thymine dimers formation and reduces sunburn lesions in the epidermis of experimental mice [ 35 , 36 ]. Topical application of caffeine enhanced the UVB-induced apoptosis, but it was inactive on non-UVB-treated normal skin in the hairless SKH-1 mice [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

et al. 2016

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BackgroundSeveral epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk.MethodsStudies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model.ResultsTwo case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68–0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912–0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81–1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake).ConclusionsThis meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

et al. 2016

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“…In the 1970 s Zajdela and Latajet described the striking re-duction of skin tumor formation by topical caffeine in UV-irradiated Swiss mice [56], [57]. A few years later, Bowden and Fussenig showed a correlation between the synergistic cytotoxic effects of caffeine and UV radiation and inhibition of DNA elongation in an immortalized epidermal cell line and showed that mouse primary keratinocytes have a post-replication DNA repair mechanism that is inhibited by caffeine [58], [59]. The extensive studies of Conney and his colleagues on the chemoprotective properties of tea in SKH-1 hairless mice that were rendered high-risk for skin cancer development by prior chronic exposure to low doses of UVB radiation demonstrated that decaffeinated beverages had little protective effect, whereas adding caffeine back restored protection [60].…”

Section: Alkaloids !mentioning

confidence: 99%

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Dinkova‐Kostova

2008

Planta Med

121

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Plants and animals have evolved utilizing the beneficial effects of sunlight for fundamental processes such as photosynthesis and vision. Paradoxically, the ultraviolet (UV) component of the solar spectrum represents one of the most ubiquitous carcinogens in our environment. Furthermore, there is growing concern that its levels are increasing as a result of depletion of the stratospheric ozone and climate change [1], [2], [3]. Based on wavelength, the UV spectrum is commonly divided into three regions: UVA (400-320 nm), UVB (320-290 nm), and UVC (290-200 nm).

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Caffeine enhancement of the initiation of DNA replication in benzo[a]pyrene diol epoxide damaged cells

Bowden

Rosenthal

1983

Chemico-Biological Interactions

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Caffeine inhibition of postreplication repair of UV-damaged DNA in mouse epidermal cells

Cited by 4 publications

References 32 publications

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Caffeine enhancement of the initiation of DNA replication in benzo[a]pyrene diol epoxide damaged cells

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