Caffeine intake by patients with autosomal dominant polycystic kidney disease

Abstract

Because caffeine may induce cyst and kidney enlargement in autosomal dominant polycystic kidney disease (ADPKD), we evaluated caffeine intake and renal volume using renal ultrasound in ADPKD patients. Caffeine intake was estimated by the average of 24-h dietary recalls obtained on 3 nonconsecutive days in 102 ADPKD patients (68 females, 34 males; 39 ± 12 years) and compared to that of 102 healthy volunteers (74 females, 28 males; 38 ± 14 years). The awareness of the need for caffeine restriction was assessed. Clinical and laboratory data were obtained from the medical records of the patients. Mean caffeine intake was significantly lower in ADPKD patients versus controls (86 vs 134 mg/day), and 63% of the ADPKD patients had been previously aware of caffeine restriction. Caffeine intake did not correlate with renal volume in ADPKD patients. There were no significant differences between the renal volumes of patients in the highest and lowest tertiles of caffeine consumption. Finally, age-adjusted multiple linear regression revealed that renal volume was associated with hypertension, chronic kidney disease stage 3 and the time since diagnosis, but not with caffeine intake. The present small cross-sectional study indicated a low level of caffeine consumption by ADPKD patients when compared to healthy volunteers, which was most likely due to prior awareness of the need for caffeine restriction. Within the range of caffeine intake observed by ADPKD patients in this study (0-471 mg/day), the renal volume was not directly associated with caffeine intake.

Predictors of Autosomal Dominant Polycystic Kidney Disease Progression

“…96 High caffeine intake may, therefore, be a risk factor for cyst enlargement and ADPKD progression, although a small clinical study has suggested no correlation between mild caffeine intake and TKV by ultrasound. 97 Nevertheless, it is recommended to counsel patients with ADPKD to limit their caffeine intake.…”

Exercise partially reverses the inhibitory effect of caffeine on liver gluconeogenesis in type 1 diabetic rats with hypoglycemia

“…Caffeine is avoided in some cases, such as autosomal dominant polycystic kidney disease, due to prior awareness of the patients of need for restriction, because caffeine may induce cyst and kidney enlargement (45). However, in other cases, in spite of not having nutritional value, caffeine has been used as an ergogenic substance because it improves performance in long-term physical activities.…”

Polycystic Kidney Disease and the Vasopressin Pathway

“…However, a majority of these patients (63%) had previously been advised to lower coffee consumption, and the mean coffee intake was significantly lower compared to healthy controls (86 ± 77 vs. 134 ± 116 mg/day, p ≤ 0.001) [39] .…”

“…Hypothetically, caffeine has a specific deleterious effect in PKD via PDE inhibition, but when analyzing the effects of caffeine intake in a case-control study in 102 van ADPKD patients, no associations were found between coffee intake and eGFR or TKV [39] . However, a majority of these patients (63%) had previously been advised to lower coffee consumption, and the mean coffee intake was significantly lower compared to healthy controls (86 ± 77 vs. 134 ± 116 mg/day, p ≤ 0.001) [39] .…”