Caffeine intake is associated with pupil dilation and enhanced accommodation

Abokyi, Samuel; Owusu-Mensah, J; Osei, Kwaku A.

doi:10.1038/eye.2016.288

Cited by 47 publications

(48 citation statements)

References 20 publications

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“…Unfortunately, we did not notice whether the participants had consumed caffeine prior to pupillometry. This could potentially affect the pupillometry outcomes, since caffeine has been associated with pupil dilation and increased accommodation (Abokyi et al 2017) In conclusion, this is the first study to investigate the function of ipRGCs and sleep quality in patients with NTG. We found that the melanopsin-mediated PLR was significantly reduced in patients with NTG, indicating impaired ipRGC activity.…”

Section: Discussionmentioning

confidence: 88%

Melanopsin‐mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

Ahmadi

Lund‐Andersen

Kolko

et al. 2019

Acta Ophthalmologica

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Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) and sleep quality are impaired in patients with primary open-angle glaucoma (POAG). In this study, we investigated whether ipRGCs and sleep quality were also impaired in patients with normal tension glaucoma (NTG). Methods: We performed pupillometry and sleep quality assessment in 15 patients with NTG and 17 healthy age-matched controls. Pupillometry protocol consisted of monocular stimulation with high illuminance (100 lux) red (633 nm, 300 cd/m 2 or 15.23 log quanta/cm 2 /s) and blue light (463 nm, 332 cd/m 2 or 15.27 log quanta/cm 2 /s) and binocular pupil measurements. Prior to light stimulation, patients were dark-adapted for 5 min. The late postillumination pupillary response (PIPR Late ) to blue light was used as marker of ipRGC activity. Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: The PIPR Late to blue light was significantly reduced in patients with NTG compared to healthy subjects (p < 0.001), indicating impairment of the melanopsin-mediated pupillary pathway. There was no significant difference in the response elicited by red light (p = 0.6). Baseline pupil diameter and pupillary constriction amplitude to both red and blue light were reduced in patients with NTG (p < 0.05). The global score in PSQI was not significantly different between healthy controls and patients with NTG, indicating normal sleep quality (p = 0.6). Furthermore, we found no correlation between sleep parameters and pupillary light reflex parameters. Conclusion: Patients with NTG exhibited reduced ipRGC activity compared to healthy subjects, while no differences were observed in sleep quality.

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Section: Discussionmentioning

confidence: 88%

Melanopsin‐mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

Ahmadi

Lund‐Andersen

Kolko

et al. 2019

Acta Ophthalmologica

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“…All reported having normal or corrected-to-normal vision and hearing and having no diagnosed neurological disease. No participants reported having used psychoactive substances up to 12 hours pre-experiment, as well as having consumed coffee, tea, or tobacco products up to 6 hours before the experiment as this could impact the baseline pupil diameter (Abokyi, Owusu-Mensah, & Osei, 2017;Lie & Domino, 1999).…”

Section: Methods Participantsmentioning

confidence: 99%

Is auditory distraction by changing-state and deviant sounds underpinned by the same mechanism? Evidence from pupillometry

Marois

Marsh

Vachon

2019

Biological Psychology

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The mere presence of task-irrelevant auditory stimuli is known to interfere with cognitive functioning. Disruption can be caused by changing auditory distractors (the changing-state effect) or by a sound that deviates from the auditory background (the deviation effect). The unitary account of auditory distraction explains both phenomena in terms of attentional capture whereas the duplex-mechanism account posits that they reflect two fundamentally different forms of distraction in which only the deviation effect is caused by attentional capture. To test these predictions, we exploited a physiological index of attention orienting: the pupillary dilation response (PDR). Participants performed visual serial recall while ignoring sequences of spoken letters. These sequences either comprised repeated or changing letters, and one letter could sometimes be replaced by pink noise (the deviant). Recall was poorer in both changing-state and deviant trials. Interestingly, the PDR was elicited by deviant sounds but not changing-state sounds. This physiological dissociation of the changing-state and the deviation effects suggests they are subtended by distinct mechanisms thereby procuring support for the duplex-mechanism account over the unitary account.

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“…Pupil dilations are larger after ingestion of caffeine ( Abokyi, Oqusu-Mensah, & Osei, 2017 ). Caffeine has been shown to affect the pupil response for up to about 6 h, particularly in people who do not routinely consume it ( Wilhelm, Stuiber, Lüdtke, & Wilhelm, 2014 ).…”

Section: Data Collectionmentioning

confidence: 99%

Best Practices and Advice for Using Pupillometry to Measure Listening Effort: An Introduction for Those Who Want to Get Started

et al. 2018

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Within the field of hearing science, pupillometry is a widely used method for quantifying listening effort. Its use in research is growing exponentially, and many labs are (considering) applying pupillometry for the first time. Hence, there is a growing need for a methods paper on pupillometry covering topics spanning from experiment logistics and timing to data cleaning and what parameters to analyze. This article contains the basic information and considerations needed to plan, set up, and interpret a pupillometry experiment, as well as commentary about how to interpret the response. Included are practicalities like minimal system requirements for recording a pupil response and specifications for peripheral, equipment, experiment logistics and constraints, and different kinds of data processing. Additional details include participant inclusion and exclusion criteria and some methodological considerations that might not be necessary in other auditory experiments. We discuss what data should be recorded and how to monitor the data quality during recording in order to minimize artifacts. Data processing and analysis are considered as well. Finally, we share insights from the collective experience of the authors and discuss some of the challenges that still lie ahead.

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Caffeine intake is associated with pupil dilation and enhanced accommodation

Cited by 47 publications

References 20 publications

Melanopsin‐mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

Melanopsin‐mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

Is auditory distraction by changing-state and deviant sounds underpinned by the same mechanism? Evidence from pupillometry

Best Practices and Advice for Using Pupillometry to Measure Listening Effort: An Introduction for Those Who Want to Get Started

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