Caffeine phenotyping in patients with familial adenomatous polyposis may shed light on sporadic colon cancer and acetylator status.

Phytoestrogens and Colon Cancer

“…Furthermore, an enhanced risk for CRC and colonic adenomas is present in individuals whose first-degree relatives are affected by CRC, especially if the tumor occurs before the age of 60 [8]. Possible factors of this inherited susceptibility to CRC are polymorphisms of genes deputed to glutathione synthesis such as GSTP1, GSTM1 and GSTT1 genes [11].…”