Caffeine prevents high-intensity exercise-induced increase in enzymatic antioxidant and Na⁺-K⁺-ATPase activities and reduction of anxiolytic like-behaviour in rats

Abstract

HIIT-induced anxiolytic-like behaviour increased Na-K-ATPase and GPx activities and TBARS levels, altered the activities of SOD and CAT in different brain regions, and decreased GSH levels. Caffeine, however, elicited anxiogenic-like behaviour and blocked HIIT effects. The combination of caffeine and HIIT prevented the increase in SOD activity in the cerebral cortex and GPx activity in three brain regions. Our results show that caffeine promoted anxiogenic behaviour and prevented HIIT-induced changes in the antioxidant system and Na-K-ATPase activities.

Effects of Dietary Supplements on Adaptations to Endurance Training

“…Despite the above rationale, only one study in humans, and one study in rats, has investigated the effects of caffeine on adaptations to endurance training. In the human study, the caffeine was part of a multi-ingredient supplement, dietary caffeine intake was not controlled for, and there were no differences in caffeine consumption between groups [173], while rats given caffeine prior to each exercise session during six weeks of HIIT were only studied for changes in brain and behavioral biomarkers [174]. Research should investigate the effects of caffeine on training adaptations, in conjunction with the impact of exercise intensity, training status [175], sex [176], and genotype [177], using moderate (3 to 6 mg/kg) and low (<3 mg/kg) [178] doses.…”

Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

“…In the context of the rat brain, a notable interplay emerged between chronic high-intensity interval training (HIIT) and caffeine consumption, revealing a linkage to the activity of Na + -K + -ATPase and antioxidant enzymes within the brain, alongside the manifestation of anti-anxiety behaviors. Notably, caffeine administration was observed to amplify anxiety-related behaviors, while concurrently mitigating alterations induced by HIIT in the antioxidant system and Na + -K + -ATPase activity[ 106 ]. This implies that caffeine could potentially heighten AMP degradation through the modulation of ATPase activity.…”

Moléculas nutracêuticas e sistema purinérgico

“…Além dos compostos fenólicos, como o ácido clorogênico e o ácido cafeico, as atividades biológicas do café também são atribuídas aos terpenos e alcaloides, sendo o alcaloide cafeína o mais conhecido. O café e suas substâncias bioativas têm demonstrado propriedades antioxidantes, anti-inflamatórias, hipoglicemiantes, neuroprotetoras e cardioprotetoras (Andersen et al, 2006;Cunha;Agostinho, 2010;Stefanello et al, 2016Stefanello et al, , 2019Vieira et al, 2017).…”