Caffeine promotes ethanol drinking in rats

Kunin, Daniel; Gaskin, Stéphane; Rogan, Franc; Smith, Brian R.; Amit, Zalman

doi:10.1016/s0741-8329(00)00101-4

Cited by 70 publications

(30 citation statements)

References 27 publications

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“…Previous studies have either systemically injected caffeine (Kunin et al, 2000, Rezvani et al, 2013) or forced continuous access for long durations (Hughes, 2011). In the present study, we demonstrated that male B6 mice will not only voluntarily consume behaviorally relevant levels of caffeine, but will also consume combined ethanol/caffeine solutions via DID, reaching BECs equivalent to animals that consume ethanol alone.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, it is important to note that differences between the E and EC groups outlined above cannot be due to differential ethanol pharmacokinetics (Figure 5D). Previous studies have also shown that caffeine (Kunin et al, 2000) or energy drink administration (Ferreira et al, 2004) does not alter ethanol metabolism in rodents when simultaneously administered.…”

Section: Discussionmentioning

confidence: 99%

“…However, little work has been published in this regard (for review, see Lopez-Cruz et al, in press ). The available literature suggests that caffeine administration may both increase (Kunin et al, 2000) and decrease (Rezvani et al, 2013) ethanol intake, as well as reduce various aspects of ethanol-induced motor (Dar, 1988, Yacoubi et al, 2000) and cognitive impairment (Spinetta et al, 2008). Caffeine has also been demonstrated to enhance the locomotor stimulant properties of ethanol in mice (Hilbert et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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“Wired,” Yet Intoxicated: Modeling Binge Caffeine and Alcohol Co‐Consumption in the Mouse

Fritz

Companion

Boehm

2014

Alcoholism Clin & Exp Res

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Background The combination of highly caffeinated ‘energy drinks’ with alcohol (ethanol) has become popular among young adults and intoxication via such beverages has been associated with an elevated risk for harmful behaviors. However, there are discrepancies in the human literature regarding the effect of caffeine on alcohol intoxication, perhaps due to confounding factors such as personality type, expectancy, and history of exposure. Animal models of co-exposure are resistant to such issues, however, the consequences of voluntary co-consumption have been largely ignored in the animal literature. The primary goal of this work was to characterize a mouse model of binge caffeine and ethanol co-consumption employing the limited-access ‘Drinking-in-the-Dark’ paradigm (DID). Methods Caffeine was added to a 20% alcohol solution via DID. Alcohol/caffeine intake, locomotor behavior, ataxia, anxiety-like behavior, and cognitive function were evaluated as a consequence of co-consumption in adult male C57BL/6J mice. Results Caffeine did not substantially alter binge alcohol intake or resultant BECs, nor did it alter alcohol’s anxiolytic effects on the elevated plus maze or cognitive interfering effects in a novel object recognition task. However, no evidence of alcohol-induced sedation was observed in co-consumption groups that instead demonstrated a highly stimulated state similar to that of caffeine alone. The addition of caffeine was also found to mitigate alcohol-induced ataxia. Conclusions Taken together, our mouse model indicates that binge co-consumption of caffeine and alcohol produces a stimulated, less ataxic and anxious, as well as cognitively altered state; a state that could be of great public health concern. These results appear to resemble the colloquially-identified ‘wide awake drunk’ state that individuals seek via consumption of such beverages. This self-administration model therefore offers the capacity for translationally-valid explorations of the neurobiological consequences of binge co-consumption in order to assess the public health risk of this drug combination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

“Wired,” Yet Intoxicated: Modeling Binge Caffeine and Alcohol Co‐Consumption in the Mouse

Fritz

Companion

Boehm

2014

Alcoholism Clin & Exp Res

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“…With regards to animal models, a recent review nicely summarizes the growing research with caffeine/ethanol combinations (Lopez-Cruz et al , 2013). Previous work has shown that caffeine can increase ethanol drinking in rats (Kunin et al , 2000; Rezvani et al , 2013) and can promote significant ethanol-induced taste aversions (Kunin et al , 2001). Additionally, it has been reported that combinations of caffeine and ethanol, compared to either drug alone, increase locomotor activity after acute injection (Hilbert et al , 2013) or while consuming the drug mixtures in a drinking paradigm (Fritz et al , 2014).…”

Section: Introductionmentioning

confidence: 99%

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

May

Haun

Griffin

2015

Alcohol Clin Exp Res

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Introduction Energy drinks are popular mixers with alcohol. While energy drinks contain many ingredients, caffeine is an important pharmacologically active component and is generally present in larger amounts than in other caffeinated beverages. In these studies, we investigated the hypothesis that caffeine would influence the effects of alcohol (ethanol) on conditioned taste aversion, ataxia and locomotor activity after repeated exposure. Methods Four groups of mice were exposed by oral gavage twice daily to vehicle, ethanol (4 g/kg), caffeine (15 mg/kg), or the ethanol/caffeine combination. Conditioned taste aversion to saccharin and ataxia in the parallel rod task were evaluated after 8 or 16 gavages, respectively, using ethanol (1–3 g/kg) or ethanol/caffeine (3mg/kg + 2 g/kg) challenges. In addition, locomotor activity was evaluated initially and after repeated exposure to oral gavage of these drugs and doses. Results Repeated oral gavage of ethanol produced significant locomotor sensitization, with those mice increasing total distance traveled by 2-fold. The locomotor response to caffeine, while significantly greater than vehicle gavage, did not change with repeated exposure. On the other hand, repeated gavage of caffeine/ethanol combination produced a substantial increase in total distance traveled after repeated exposure (~4-fold increase). After repeated ethanol exposure, there was significant tolerance to ethanol in the conditioned taste aversion and parallel rod tests. However, neither a history of caffeine exposure nor including caffeine influenced ethanol-induced conditioned taste aversion. Interestingly, a history of caffeine exposure increased the ataxic response to the caffeine/ethanol combination and appeared to reduce the ataxic response to high doses of ethanol. Conclusion The data support the general hypothesis that repeated exposure to caffeine influences the response to ethanol. Together with previously published work, these data indicate that caffeine influences some ethanol-related behaviors, notably locomotion and ataxia, but appears not to influence the expression of conditioned behaviors.

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“…Further, field research has linked co-consumption of caffeine and alcohol with increased breath alcohol concentration or a greater number of alcohol drinks consumed (Pennay et al 2015; Thombs et al 2010; Thombs et al 2011; Verster et al 2015). Animal research also suggests that some caffeine doses are associated with increased alcohol consumption (Dietze and Kulkosky 1991; Kunin et al. 2000; Rezvani et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeine on alcohol reinforcement: beverage choice, self-administration, and subjective ratings

et al. 2017

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Rationale Combining alcohol and caffeine is associated with increased alcohol consumption, but no prospective experimental studies have examined whether added caffeine increases alcohol consumption. Objectives This study examined how caffeine alters alcohol self-administration and subjective reinforcing effects in healthy adults. Methods Thirty-one participants completed six double-blind alcohol self-administration sessions: three sessions with alcohol only (e.g., Beverage A) and three sessions with alcohol and caffeine (e.g., Beverage B). Participants chose which beverage to consume on a subsequent session (e.g., Beverage A or B). Effects of caffeine on overall beverage choice, number of self-administered drinks, subjective ratings (e.g., Biphasic Alcohol Effects Scale), and psychomotor performance were examined. Results A majority of participants (65%) chose to drink the alcohol beverage containing caffeine on their final self-administration session. Caffeine did not increase the number of self-administered drinks. Caffeine significantly increased stimulant effects, decreased sedative effects, and attenuated decreases in psychomotor performance attributable to alcohol. Relative to nonchoosers, caffeine choosers reported overall lower stimulant ratings, and reported greater drinking behavior prior to the study. Conclusions Although caffeine did not increase the number of self-administered drinks, most participants chose the alcohol beverage containing caffeine. Given the differences in subjective ratings and pre-existing differences in self-reported alcohol consumption for caffeine choosers and nonchoosers, these data suggest decreased stimulant effects of alcohol and heavier self-reported drinking may predict subsequent choice of combined caffeine and alcohol beverages. These predictors may identify individuals who would benefit from efforts to reduce risk behaviors associated with combining alcohol and caffeine.

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Caffeine promotes ethanol drinking in rats

Cited by 70 publications

References 27 publications

“Wired,” Yet Intoxicated: Modeling Binge Caffeine and Alcohol Co‐Consumption in the Mouse

“Wired,” Yet Intoxicated: Modeling Binge Caffeine and Alcohol Co‐Consumption in the Mouse

Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice

Effects of caffeine on alcohol reinforcement: beverage choice, self-administration, and subjective ratings

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