Caffeine-Related Genital Skin Pain

Markos, A R

doi:10.1097/lgt.0b013e318153f7d4

Cited by 4 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This cumulatively provides a plausible explanation for the caffeine-induced genital skin dysaesthesia. 31 Erythromelalgia and dysfunctional micro-vascular arteriovenous shunting. RSS 15 referred first to male patients complaining of episodes of unexplained scrotal burning sensation and hyperaemia, with no underlying clear pathology.…”

Section: Similarities Between Pgad Regs and Vulvodyniamentioning

confidence: 99%

“…38 Comparisons between PGAD, ReGS and vulvodynia are further supported by the response of both conditions to neuro-tropic drugs, dual SSRIs and SNRIs and TENS. [1][2][3][4][5][6]8,26,27 ReGS comparison with penoscrotodynia 7,30,31,36 and RSS 15,16 could be explained as dysfunctional micro-vascular arterio-venous shunting and erythromelalgia. 18,19,20 This indicates strong comparison between penoscrotodynia, RSS and ReGS cases, particularly those with concurrent RLS.…”

Section: The Evolvement Of Nomenclaturesmentioning

confidence: 99%

See 1 more Smart Citation

Persistent genital arousal and restless genitalia: sexual dysfunction or subtype of vulvodynia?

Markos

Dinsmore

2013

Int J STD AIDS

View full text Add to dashboard Cite

We conducted a literature review of patients' conditions described under persistent genital arousal disorder and restless genital syndrome, vulvodynia and male genital skin pain of unknown aetiology (penoscrotodynia). Our aim is to improve the understanding of the condition, unify nomenclature and promote evidence-based practice. The most prominent symptom in persistent genital arousal disorder and restless genital syndrome is a spontaneous, unwelcomed, intrusive and distressing vulval sensation. There are similarities between the clinical presentation of vulvodynia, penoscrotodynia, persistent genital arousal disorder and restless genital syndrome patients. The aetiology of persistent genital arousal disorder and restless genital syndrome, similar to vulvodynia, could be better explained in terms of neuro-vascular dysfunction, genital peripheral neuropathy and/or dysfunctional micro-vascular arterio-venous shunting. Erythromelalgia lends itself to explain some cases of restless genital syndrome, who have concurrent restless legs syndrome; and therefore draw parallels with the red scrotum syndrome. The published literature supports the concept of classifying restless genital syndrome as a sub-type of vulvodynia rather than sexual dysfunction.

show abstract

Section: Similarities Between Pgad Regs and Vulvodyniamentioning

confidence: 99%

Section: The Evolvement Of Nomenclaturesmentioning

confidence: 99%

Persistent genital arousal and restless genitalia: sexual dysfunction or subtype of vulvodynia?

Markos

Dinsmore

2013

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

“…6 Caffeine-induced genital skin pain may be produced by intake of beverages containing caffeine, with cessation of the burning/ pain on abstinence. 7 The effect of caffeine on peripheral nerves is extrapolated from research. The experimental use of caffeine led to blockage of the alleviation of hyperalgesia, produced by the chronic administration of amitriptyline.…”

Section: Aetiologymentioning

confidence: 99%

“…On reflection, it seems unreasonable to offer a biopsy for what otherwise looks like normal and healthy skin, which was the case in all the published case reports 10,11 and other cases of DPSD we encounter in our practice. 2,3,7 The second practical difficulty is choosing the site of the biopsy, when there is no single area of the genital skin that looks different from the others. Thirdly, it would be difficult to justify the normality of the histological findings to the patients when the biopsy was deemed essential for diagnosis.…”

Section: Skin Biopsymentioning

confidence: 99%

“…1,2,10,11 Amitriptyline, gabapentin, pregabalin, carbamazepine or paroxetine have all been used with variable degrees of reported success. 2,3,7,10,11 There is also an indication of efficacy of cognitive-behavioural therapy in provoked vulvodynia, 38,39 which opens the door for a similar approach with DPSD. The current collective evidence and guidelines into the management of peripheral neuropathy suggests that tricyclic antidepressants, SSRIs/SNRIs, calcium channel alpha(2)-delta ligands (i.e.…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Dysaesthetic penoscrotodynia: nomenclature, classification, diagnosis and treatment

Markos¹

2011

Int J STD AIDS

View full text Add to dashboard Cite

Male patients can present with a genital skin burning sensation that bears similarities to vulvodynia. The classification of vulvodynia by International Society for the Study of Vulvovaginal Disease of vulvodynia provides a blueprint for nomenclature and classification of Dysaesthetic penoscrotodynia (DPSD). Recognizing DPSD as generalized, localized, provoked, unprovoked and mixed will enable precise and objective communication between practitioners. Learning from research on the aetiology and management of vulvodynia can improve the care of patients suffering with DPSD. Scope remains for better acknowledgement of DPSD within the medical profession and improvement in its public profile in order to enhance patient care.

show abstract

Differentiation of Restless Genital Syndrome from Persistent Genital Arousal Disorder: A Case Report

Haghshenas,

Poor

2025

CPRR

View full text Add to dashboard Cite

Objective: Persistent genital arousal disorder (PGAD) presents with a constant unwelcome sensation of genital arousal. Moreover, restless genital syndrome (RGS) is one of the restless leg syndrome (RLS) variants. Case Representation: We aimed to clarify the differences between clinical diagnoses of these two similar conditions. Assessing the circadian pattern of symptoms, the simultaneous presence of RLS and restless bladder syndrome, exacerbation of symptoms with caffeine use, healing with magnesium use, and familial history of RLS helped us with the differentiation between PGAD and RGS. Conclusion: We propose to rule out the diagnosis of RGS in all patients with PGAD symptoms.

show abstract

Caffeine-Related Genital Skin Pain

Abstract: Genital hyperesthesia is more recognized in women but may affect men. We report both a female and a male patient in whom caffeine intake was associated with genital hyperesthesia.

Cited by 4 publications

References 7 publications

Persistent genital arousal and restless genitalia: sexual dysfunction or subtype of vulvodynia?

Persistent genital arousal and restless genitalia: sexual dysfunction or subtype of vulvodynia?

Dysaesthetic penoscrotodynia: nomenclature, classification, diagnosis and treatment

Differentiation of Restless Genital Syndrome from Persistent Genital Arousal Disorder: A Case Report

Contact Info

Product

Resources

About