Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway

Gao, Lin; Sun, Weixi; Zhang, Lei; Liang, Caixia; Zhang, Dongmei

doi:10.1007/s13365-024-01222-x

J. Neurovirol.

2024

DOI: 10.1007/s13365-024-01222-x

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Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway

Lin Gao,

Weixi Sun,

Lei Zhang

et al.

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Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

Nie,

Luo,

Liu

et al. 2024

Nutrients

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Alzheimer’s disease (AD) is a complex multifactorial neurodegenerative disease. With the escalating aging of the global population, the societal burden of this disease is increasing. Although drugs are available for the treatment of AD, their efficacy is limited and there remains no effective cure. Therefore, the identification of safe and effective prevention and treatment strategies is urgently needed. Functional factors in foods encompass a variety of natural and safe bioactive substances that show potential in the prevention and treatment of AD. However, current research focused on the use of these functional factors for the prevention and treatment of AD is in its initial stages, and a complete theoretical and application system remains to be determined. An increasing number of recent studies have found that functional factors such as polyphenols, polysaccharides, unsaturated fatty acids, melatonin, and caffeine have positive effects in delaying the progression of AD and improving cognitive function. For example, polyphenols exhibit antioxidant, anti-inflammatory, and neuroprotective effects, and polysaccharides promote neuronal growth and inhibit inflammation and oxidative stress. Additionally, unsaturated fatty acids inhibit Aβ production and Tau protein phosphorylation and reduce neuroinflammation, and melatonin has been shown to protect nerve cells and improve cognitive function by regulating mitochondrial homeostasis and autophagy. Caffeine has also been shown to inhibit inflammation and reduce neuronal damage. Future research should further explore the mechanisms of action of these functional factors and develop relevant functional foods or nutritional supplements to provide new strategies and support for the prevention and treatment of AD.

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Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

Nie,

Luo,

Liu

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

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Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway

Cited by 1 publication

References 68 publications

Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

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