Caffeinism complicating hypersomnic depressive episodes

Neil, John F.; Himmelhoch, Jonathan M.; Mallinger, Alan G.; Mallinger, J.; Hanin, Israel

doi:10.1016/0010-440x(78)90021-4

Cited by 43 publications

(19 citation statements)

References 22 publications

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“…However, the frequency of rearing and grooming for the caffeine-fed group was statistically lower compared to the control. The decrease in locomotor activity following chronic consumption of caffeine is in consonance with the reports of Neil (1978) which showed that chronic consumption of caffeine caused mixed depressive states in psychiatric patients. In support, the work of Greden et al (1978) also reported depressive syndrome following chronic consumption of caffeine.…”

Section: Discussionsupporting

confidence: 76%

The Comparative Effects Of Chronic Consumption Of Kola Nut (Cola nitida) And Caffeine Diets On Locomotor Behaviour And Body Weights In Mice

Umoren¹,

Osim²,

Udoh³

2009

Nig. J. Phys Sci

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Summary:The comparative effects of chronic (28 days) consumption of kola nut and its active constituent, caffeine diets on locomotor behaviour and body weights in mice were investigated. 30 adult Swiss white mice (15-30g body weight), were used for the study. The open field-maze was employed for the evaluation of locomotor behaviour. Mice in the control group (n = 10) were fed normal rodent chow, mice in the kola nut-fed group (n = 10) were fed kola diet (25% wt/wt of rodent chow) while those in the caffeine-fed group (n = 10) were fed caffeine diet (0.66% wt/wt of rodent chow) for 4 weeks. All animals were allowed free access to clean drinking water. Daily food intake, water intake and body weight change were also measured. Daily food intake in the kola nut and caffeine-fed group of mice was significantly (P<0.001 respectively) lower than the control. There was also a significant (P<0.001) decrease in daily water intake in the caffeine-fed group compared to the control whereas, the apparent decrease of water intake in the kola nut-fed group was not significantly different from the control. Body weight change was also significantly (P<0.001 and P<0.05 respectively) lower in the kola nut and caffeine-fed groups of mice when compared to the control. The frequency of rearing in the open field was significantly (P<0.01) lower in the caffeine-fed group of mice when compared to the control. The frequency of grooming was also significantly (P<0.05) lower in the caffeine-fed group of mice when compared to the control. There was also a significant (P<0.05) decrease in the frequency of light-dark transitions in the light/dark transition box for the caffeine-fed group when compared to the control. The results showed that chronic consumption of kola nut and caffeine diets caused decrease in food intake and body weight. Consumption of caffeine-diet also significantly decreased water intake and locomotor activity. The effect of kola nut-diets on water intake and locomotor activity was not significant. Hence, the effect of kola nut on locomotor behaviour and water intake may not be due to caffeine only.

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Section: Discussionsupporting

confidence: 76%

The Comparative Effects Of Chronic Consumption Of Kola Nut (Cola nitida) And Caffeine Diets On Locomotor Behaviour And Body Weights In Mice

Umoren¹,

Osim²,

Udoh³

2009

Nig. J. Phys Sci

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“…Although concerns have been raised about ignoring caffeine use in studies of psychiatric patients (Hughes and Howard, 1997), our findings suggest that caffeine use might not have a significant clinical contribution in higher functioning outpatients. Caffeine use was modestly correlated with depressive symptoms, consistent with previous reports (Gilliland and Andress, 1981;Greden et al, 1978) and the hypothesis that caffeine may have antidepressant effects (Neil et al, 1978;Leibenluft et al, 1993), though this association may also suggest caffeine induces depressive symptoms.…”

Section: Discussionsupporting

confidence: 87%

“…In a study exploring the normal pattern of caffeine use among college students, those with greater consumption reported highest depression scores (Gilliland and Andress, 1981), and similar results were found among psychiatric inpatients (Greden et al, 1978). Further, some investigators suggest caffeine may treat dysphoria and act as a weak, temporary antidepressant (Neil et al, 1978;Leibenluft et al, 1993). The net pharmacologic net effect may be obscured by direct effects of caffeine in conjunction with underlying mood or anxiety symptoms.…”

Section: Introductionmentioning

confidence: 99%

Caffeine use and plasma concentrations in psychiatric outpatients

Lande

Labbate

1998

Depress. Anxiety

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“…Sattin (1984) has suggested that adenosine itself may be involved in the affective disorders and this proposal warrants further consideration. Neil et al (1978) have demonstrated a failure of patients who are coffee users to respond to conventional antidepressant therapy and Sattin (1984) has reported anecdotal evidence to suggest a pharmacodynamic induction of behavioural disorders by caffeine. Adenosine may therefore be involved in the affective disorders.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants

Phillis

1984

British J Pharmacology

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1The effects of four tricyclic antidepressants, nortriptyline, iprindole, chlorimipramine and desipramine on adenosine-evoked depressions of the firings of rat cerebral cortical neurones has been studied. 2 When applied iontophoretically, all four substances enhanced the depressant actions of iontophoretically applied adenosine but did not affect the depressant actions of the uptake-resistant analogue, adenosine 5 '-N-ethylcarboxamide (NECA).3 Nortriptyline and iprindole administered intravenously (1 mg kg-') enhanced the depressant actions of iontophoretically applied adenosine. 4 When applied by larger iontophoretic currents, all four antidepressants inhibited the firing of cerebral cortical neurones. Chlorimipramine-and desimipramine-elicited depressions were antagonized by intravenously administered caffeine, an adenosine antagonist. 5 Earlier studies showed the tricyclic antidepressants inhibit the uptake of adenosine by rat brain cerebral cortical synaptosomes. The present results demonstrate that four antidepressants are able to potentiate the action of adenosine and that this occurs when these compounds are given in behaviourally meaningful doses. The specificity of the potentiation is demonstrated by the failure of these compounds to potentiate the depressant actions of an uptake-resistant analogue of adenosine, NECA. 6 Antagonism of the inhibitory effects of the antidepressants on neuronal firings by caffeine, indicates that these compounds can enhance the extracellular levels of endogenously released adenosine sufficiently to depress cell firing.

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Caffeinism complicating hypersomnic depressive episodes

Cited by 43 publications

References 22 publications

The Comparative Effects Of Chronic Consumption Of Kola Nut (Cola nitida) And Caffeine Diets On Locomotor Behaviour And Body Weights In Mice

The Comparative Effects Of Chronic Consumption Of Kola Nut (Cola nitida) And Caffeine Diets On Locomotor Behaviour And Body Weights In Mice

Caffeine use and plasma concentrations in psychiatric outpatients

Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants

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