Caffeoyl phenols and alkamides of cultivatedEchinacea purpureaandEchinacea atrorubensvar.paradoxa

Chen, Chung Li; Zhang, Shih Chan; Sung, Jih Min

doi:10.1080/13880200902939291

Cited by 10 publications

(13 citation statements)

References 24 publications

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“…On the basis of data obtained in this work, the R and SL extracts displayed different alkamide profiles, with twelve and ten compounds, respectively identified comparing their HPLC elution orders, ESI-MS/MS, and PDA/UV spectra with data reported in the literature 3 , 26 – 29 . The most abundant alkamides were the 2,4-diene type compounds and the two isomers dodeca-2 E ,4 E ,8 Z ,10 Z -tetraenoic acid isobutylamide ( 7 ) and dodeca-2 E ,4 E ,8 Z ,10 E tetraenoic acid isobutylamide ( 8 ) being predominant, according to previous studies performed on in vivo plants 30 , 31 . Moreover, seven alkamides (peaks C , E , F , H , I , J , and M ) remained not identified, and among these one alkamide (peak F ) was present only in the infected SL compartment.…”

Section: Discussionsupporting

confidence: 61%

Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model

Maggini

Leo

Mengoni

et al. 2017

Sci Rep

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The influence of the interaction(s) between the medicinal plant Echinacea purpurea (L.) Moench and its endophytic communities on the production of alkamides is investigated. To mimic the in vivo conditions, we have set up an infection model of axenic in vitro E. purpurea plants inoculated with a pool of bacterial strains isolated from the E. purpurea stems and leaves. Here we show different alkamide levels between control (not-inoculated) and inoculated plants, suggesting that the alkamide biosynthesis may be modulated by the bacterial infection. Then, we have analysed the branched-chain amino acids (BCCA) decarboxylase gene (GenBank Accession #LT593930; the enzymatic source for the amine moiety formation of the alkamides) expression patterns. The expression profile shows a higher expression level in the inoculated E. purpurea tissues than in the control ones. These results suggest that the plant-endophyte interaction can influence plant secondary metabolism affecting the therapeutic properties of E. purpurea.

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Section: Discussionsupporting

confidence: 61%

Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model

Maggini

Leo

Mengoni

et al. 2017

Sci Rep

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“…E. atrorubens var. paradoxa differs from the commercial species in that its phytochemicals, particularly alkylamides, are concentrated in the flower head, which could explain the discrepancy (Chen et al 2009 There have been several studies looking at the germination of Echinacea species and how it can be improved with various treatments (Chuanren et al 2004, Parmenter et al 1996, Romero et al 2005. In agreement with this study, untreated E. pallida var.…”

Section: Discussion: Cypsela Morphology Phytochemistry and Germinationsupporting

confidence: 81%

“…angustifolia, the roots generally have the highest levels of alkylamides, echinacoside, and cynarin, whereas flowerheads contain the highest concentration of CADs. The leaves have low levels of cichoric acid, caftaric acid, and cynarin, and are rarely used in natural health products (Chen et al 2009, Qu et al 2005, Stuart & Wills 2003, Kabganian et al 2003. This pattern of localization differs from E. atrorubens var.…”

Section: Chapter: Echinacea and Its Modern Medicinal Usesmentioning

confidence: 98%

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Phytochemical localization and fungal inhabitants in the fruits of four Echinacea taxa

Parsons¹

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Relatively little is known about the fruits of Echinacea, as they are not traditionally used in medicine. Therefore, the goal of this study was to investigate aspects of the fruits of four Echinacea taxa native to North America: E. purpurea, E. pallida var. angustifolia, E. pallida var. pallida, and E. atrorubens var. paradoxa. The alkylamide and phenolic contents of the fruits were analyzed, showing that Echinacea fruits yield valuable metabolites which could, with additional research, be incorporated into a variety of natural health products. Additionally, the effect of the fruit coatings on germination rates under different conditions was studied. Fungal endophyte and epiphyte species present within these fruits were identified to gain a better understanding of how these microbes may contribute to the health of the plant, phytochemical content, and the overall quality of Echinacea herbal products.iii

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“… 2005 ; Chen et al. 2009 ). However, ascorbic acid (vitamin C) accumulates in the leaves, which could augment immune functions (Zagumennikov et al.…”

Section: Introductionmentioning

confidence: 99%

Echinacea biotechnology: advances, commercialization and future considerations

Parsons

Cameron²,

Harris

et al. 2018

Pharmaceutical Biology

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Context: Plants of the genus Echinacea (Asteraceae) are among the most popular herbal supplements on the market today. Recent studies indicate there are potential new applications and emerging markets for this natural health product (NHP).Objective: This review aims to synthesize recent developments in Echinacea biotechnology and to identify promising applications for these advances in the industry.Methods: A comprehensive survey of peer-reviewed publications was carried out, focusing on Echinacea biotechnology and impacts on phytochemistry. This article primarily covers research findings since 2007 and builds on earlier reviews on the biotechnology of Echinacea.Results: Bioreactors, genetic engineering and controlled biotic or abiotic elicitation have the potential to significantly improve the yield, consistency and overall quality of Echinacea products. Using these technologies, a variety of new applications for Echinacea can be realized, such as the use of seed oil and antimicrobial and immune boosting feed additives for livestock.Conclusions: New applications can take advantage of the well-established popularity of Echinacea as a NHP. Echinacea presents a myriad of potential health benefits, including anti-inflammatory, anxiolytic and antibiotic activities that have yet to be fully translated into new applications. The distinct chemistry and bioactivity of different Echinacea species and organs, moreover, can lead to interesting and diverse commercial opportunities.

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Caffeoyl phenols and alkamides of cultivatedEchinacea purpureaandEchinacea atrorubensvar.paradoxa

Cited by 10 publications

References 24 publications

Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model

Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model

Phytochemical localization and fungal inhabitants in the fruits of four Echinacea taxa

Echinacea biotechnology: advances, commercialization and future considerations

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