2023
DOI: 10.1007/s12032-023-01953-7
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CAFs secrete CXCL12 to accelerate the progression and cisplatin resistance of colorectal cancer through promoting M2 polarization of macrophages

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Cited by 18 publications
(16 citation statements)
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“…Macrophages have been suggested to contribute to the EMT process and to metastasis, but their contribution may strongly depend on their mode of activation [ 39 ]. TAMs have often been shown to be activated mostly as M2, and we show here, at least partially, that this holds true also for our in vitro setting.…”
Section: Resultsmentioning
confidence: 99%
“…Macrophages have been suggested to contribute to the EMT process and to metastasis, but their contribution may strongly depend on their mode of activation [ 39 ]. TAMs have often been shown to be activated mostly as M2, and we show here, at least partially, that this holds true also for our in vitro setting.…”
Section: Resultsmentioning
confidence: 99%
“…For anti-cancer drug screening model, co-culture studies provide closer inspection of TME via interaction with cancer epithelial cells and other cellular components of the TME such as CAFs (activated fibroblasts) and endothelial cells that could influence cancer cells behaviors to chemotherapeutic agents [ 85 87 ]. Significant crosstalk has been illustrated between isolated CAFs and CRC cell lines (HCT116 and LoVo) in mediating colorectal carcinogenesis and cisplatin resistance [ 54 ]. Loss of 5-FU sensitivity was demonstrated in the co-culture of CAFs and HCT116 and DLD-1 cells [ 55 ].…”
Section: In Vitro Drug Screening Methods For Crcmentioning
confidence: 99%
“…97 Nasopharyngeal cancer cells induce immunosuppressive TAM polarization from precursor monocytes by secreting TGF-β and IL-10, which in turn produces chemoattractants that favor the accumulation of Treg. 97 CAFs have also been proven to promote immunosuppressive macrophage polarization in multiple cancer types, for example, colorectal cancer, 98 pancreatic ductal adenocarcinoma, 99 (Figure 2A). Further, γδ T cells can also exert antitumor effects by binding to IgG antibodies through CD16 (FcγR III) Fc-receptor present on their surface that promote antibody-dependent cellular cytotoxicity (ADCC) 32 (Figure 2A).…”
Section: Tumor Microenvironment and Tumor-associated Macrophage Cross...mentioning
confidence: 99%
“…Nasopharyngeal cancer cells induce immunosuppressive TAM polarization from precursor monocytes by secreting TGF‐β and IL‐10, which in turn produces chemoattractants that favor the accumulation of Treg 97 . CAFs have also been proven to promote immunosuppressive macrophage polarization in multiple cancer types, for example, colorectal cancer, 98 pancreatic ductal adenocarcinoma, 99 hepatocellular carcinoma 100 among others. In breast cancer, exosomes secreted by tumor‐associated mesenchymal stem cells induce differentiation of M‐MDSCs into more immunosuppressive TAMs with higher PD‐L1, CD206 expression, and arginase 1 activity 101 .…”
Section: Tumor Microenvironment and Tumor‐associated Macrophage Cross...mentioning
confidence: 99%