CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders

Sheikh, Ahmad Farajzadeh; Yadyad, Mohammad Jaafar; Goodarzi, Hamed; Hashemi, Seyed Jalal; Aslani, Sajad; Assarzadegan, Mohammad-Ali; Ranjbar, Reza

doi:10.1016/j.micpath.2018.06.023

Cited by 25 publications

(27 citation statements)

References 30 publications

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“…Meta-analyses[ 4 , 14 ] have shown that CagA seropositivity are correlated with the occurrence of gastric cancer among H. pylori -infected patients. Sheikh et al[ 15 ] examined 201 patients infected by H. pylori and found that cag A gene was detected in 66.7% of the isolates; positive rates of cagA gene in gastric cancer and peptic ulcer patients were 68.2% and 71%, respectively. Kim et al[ 16 ] found that H. pylori infection in South Koreans was closely related to highly virulent strains [ vacA s1/i1/m1, cagA (+), iceA1 (+), and oipA (+)] and has an intimate association with the progression of peptic ulcer diseases.…”

Section: Discussionmentioning

confidence: 99%

Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

Yuan

Zhao

Zhou

et al. 2020

WJG

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BACKGROUND Type I Helicobacter pylori ( H. pylori ) infection causes severe gastric inflammation and is a predisposing factor for gastric carcinogenesis. However, its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated; it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17 (G-17) and pepsinogens (PGs) during clinical practice. AIM To explore the prevalence of type I and type II H. pylori infection status and their impact on G-17 and PG levels in clinical practice. METHODS Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined, and 523 patients were enrolled in this study. H. pylori infection was confirmed by both 13 C-urea breath test and serological assay. Patients were divided into non-atrophic gastritis (NAG), non-atrophic gastritis with erosion (NAGE), chronic atrophic gastritis (CAG), peptic ulcers (PU) and gastric cancer (GC) groups. Their serological G-17, PG I and PG II values and PG I/PG II ratio were also measured. RESULTS A total H. pylori infection rate of 3572 examined patients was 75.9%, the infection rate of 523 enrolled patients was 76.9%, among which type I H. pylori infection accounted for 72.4% (291/402) and type II was 27.6%; 88.4% of GC patients were H. pylori positive, and 84.2% of them were type I infection, only 11.6% of GC patients were H. pylori negative. Infection rates of type I H. pylori in NAG, NAGE, CAG, PU and GC groups were 67.9%, 62.7%, 79.7%, 77.6% and 84.2%, respectively. H. pylori infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II ratio. Both types of H. pylori induced higher G-17 level, but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG, NAGE and CAG groups over uninfected controls. Overall PG I levels showed no difference among all disease groups and in the presence or absence of H. pylori; in stratified analysis, its level was increased in GC and PU patients in H. pylori and type I H. pylori- positive groups. CONCLUSION Type I H. pylori infection is the major form of infection in this geographic region, and a very low percentage (11.6%) of GC patients are not infected by H. pylori . Both types of H. pylori induce an increase in G-17 level, while type I H. pylori is the ma...

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Section: Discussionmentioning

confidence: 99%

Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

Yuan

Zhao

Zhou

et al. 2020

WJG

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“…The toxin is about 88 kDa in size and is structured into a signal (s), intermediate (i) and middle (m) region 19 . Different vacA variants have been statistically associated with pathologic features; for example, the variant s1m1 has been linked to a more severe pathology 14 , 20 . While almost all isolates from West Africa or East Asia express the s1m1 variant, the more archetypical type-2 isolates are known to lack the cagA gene and express an s2m2 vacA gene 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome

Palamides¹,

Jolaiya

Idowu

et al. 2020

Sci Rep

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Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease and classified as a WHO class I carcinogen. While the prevalence of H. pylori infections in Africa is among the highest in the world, the incidence of gastric cancer is comparably low. Little is known about other symptoms related to the H. pylori infection in Africa and the association with certain phenotypes of bacterial virulence. We established a network of study sites in Nigeria (NG) and South Africa (ZA) to gain an overview on the epidemiological situation. In total 220 isolates from 114 patients were analyzed and 118 different patient isolates examined for the presence of the virulence factors cagA, vacA, dupA , their phylogenetic origin and their resistance against the commonly used antibiotics amoxicillin, clarithromycin, metronidazole and tetracycline. We report that H. pylori isolates from Nigeria and South Africa differ significantly in their phylogenetic profiles and in their expression of virulence factors. VacA mosaicism is intensive, resulting in m1-m2 vacA chimeras and frequent s1m1 and s1m2 vacA subtypes in hpAfrica2 strains. Gastric lesions were diagnosed more frequent in Nigerian versus South African patients and H. pylori isolates that are resistant against one or multiple antibiotics occur frequently in both countries.

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“…It seems that circulating strains among Iranian patients originate from hpEurope strains, and have transferred to Iran from some groups such as Arabs in the 7-8th centuries, Uzbeks ght in 16th century, and Ottoman Empire during the 20th century (86). Existence of cagA2a genotype (EPIYA-ABC motifs) in Iran's studies con rm this hypothesis (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). However, why the number of gastric cancer cases in Iran is as high as cases of Japan, South Korea, and China?…”

Section: Discussionmentioning

confidence: 90%

“…In general, cagA genotypes recognized from around the world include AB, ABC, ABCC, ABCCC, ABCCCC, and ABD. In studies from Iran, so far there is no any document based on detection of cagA genotypes ABCCCC and ABD, which is arising from genetic differences between isolated strains of Iranian patients and East Asian's strains (37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Nevertheless, according to studies, in Iran, cagA genotypes ABCC and ABCCC are more prevalent in peptic ulcer and gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

What is the Relationship Between Helicobacter Pylori CagA Genotypes and Gastrointestinal Diseases in the Iranian Population? A Systematic Review and Meta-Analysis

Keikha¹

2020

Preprint

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Background: Helicobacter pylori (H. pylori) is one of the most well-known risk factors for getting the gastric cancer disease. In recent studies, the relationship between its virulence factors, specially CagA (cytotoxin‐associated gene A) toxin and development into the gastrointestinal diseases is taken into consideration. According to review of literature, despite the presence of four motifs A, B, C, and D in CagA toxin, two motifs C and D are more associated with gastrointestinal complications in patients who are infected by H. pylori. Methods: In the present study, we researched about theses ambiguities using a comprehensive meta-analysis study. In this study, we assessed the information of 1762 Iranian patients for potential relationship between all genotypes of cagA gene and gastrointestinal diseases.Results: According to statistical analysis, the abundance of cagA genotypes AB, ABC, ABCC, ABCCC, and ABD in Iranian population is 5.52%, 80.18%, 22.81%, 2.76%, and 0% respectively. In addition, it was determined that there is a significant relationship between cagA genotypes ABCC and ABCCC on the one hand and cagA genotype ABCCC on the other hand with susceptibility to chronic gastritis and gastric cancer respectively.Conclusions: Overall, it can be concluded that the higher number of EPIYA-C copy numbers lead to the higher risk of gastric cancer. According to our results, it seems that the presence of EPIYA-ABCCC motif in strains of H. pylori should be considered as an appropriate marker in preventing the gastric cancer among the Iranian population.

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CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders

Cited by 25 publications

References 30 publications

Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome

What is the Relationship Between Helicobacter Pylori CagA Genotypes and Gastrointestinal Diseases in the Iranian Population? A Systematic Review and Meta-Analysis

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