Cage-like amines in the synthesis and oxidation of camphor-10-sulfonic acid amides

Grignard Reagents and Their N‐analogues in the Synthesis of Tricyclic and Tetracyclic Cage‐like Lactams

“…The structures of synthesized heterocycles 11a-s were confirmed by their IR and 1 H NMR and 13 C NMR spectra. Key signals in the 1 H NMR spectra of new compounds are singlet and doublet ( 3 J 3,10 3.4-5.1 Hz) of the trans-oriented protons H 2 and H 3 (3.25-3.89 and 3.92-4.42 ppm) in norbornane subunit [4,7,8,33]. Resonance of methylene protons in ethyl group is notable in spectra of compounds 11b-h.…”

Spectral investigations, DFT computations and molecular docking studies of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-{3-[4-(2-methylphenyl)piperazin-1-yl]propyl}-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

“…In the present case, the oxygen atoms O 17 and O 18 are equally inclined from the N 15 atom given by the angles O 17 eC 16 eN 15 , O 18 eC 13 eN 15 (124.3 ) and from C 4 and C 5 atoms given by the angles O 17 eC 16 eC 5 , O 18 eC 13 eC 4 (127.4 ) as reported in the literature[56].There are four types of CeC bonds involved in the title compound, strained CeC bonds of Ring I , Ring II , Ring III and of the carbonecarbon bridge. The CeC bond lengths are in the range 1.591e1.531 Å, 1.547e1.535 Å, 1.431e1.405 Å in Ring I , Ring II , Ring III and 1.590e1.587 Å in the carbonecarbon bridge respectively.…”

Azacycloalkanes from epoxides and aziridines

“…The importance of the steric factor is obvious from the absence of the heterocyclization in the epoxidation reactions of compounds 118, 119 [121,122] and the lack of the formation of the azabrendane system at the oxidation of more bulky but also more conformationally labile camphorsulfonamide 120 (Scheme 41) [123].…”