Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

Li, Shuangdi; Zhu, Yue; Zhang, Tingting; Hang, Yuanyuan; Chen, Qiong; Jin, Yuli

doi:10.1002/bab.1715

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…However, the mechanism of how quercetin inhibits USP10 remains unclear. Another potential USP10 modulator, Cai’s Neiyi prescription (CNYP), can alleviate inflammation by inhibiting USP10 and promoting apoptosis of endometrial stromal cells, suggesting that CNYP may be an inhibitor of USP10 ( 91 ). Unlike other USP10 inhibitors, ubiquitin variant.10.1 (UbV.10.1) is a mixture of peptides and proteins with a high affinity for USP10.…”

Section: Usp10 Inhibitors and Other Modulators Of Usp10 Activitymentioning

confidence: 99%

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune response

Chen²,

Huang³

et al. 2022

Front. Oncol.

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Ubiquitin-specific peptidase 10 (USP10) is a member of the ubiquitin-specific protease family that removes the ubiquitin chain from ubiquitin-conjugated protein substrates. We performed a literature search to evaluate the structure and biological activity of USP10, summarize its role in tumorigenesis and tumor progression, and discuss how USP10 may act as a tumor suppressor or a tumor-promoting gene depending on its mechanism of action. Subsequently, we elaborated further on these results through bioinformatics analysis. We demonstrated that abnormal expression of USP10 is related to tumorigenesis in various types of cancer, including liver, lung, ovarian, breast, prostate, and gastric cancers and acute myeloid leukemia. Meanwhile, in certain cancers, increased USP10 expression is associated with tumor suppression. USP10 was downregulated in kidney renal clear cell carcinoma (KIRC) and associated with reduced overall survival in patients with KIRC. In contrast, USP10 upregulation was associated with poor prognosis in head and neck squamous cell carcinoma (HNSC). In addition, we elucidated the novel role of USP10 in the regulation of tumor immunity in KIRC and HNSC through bioinformatics analysis. We identified several signaling pathways to be significantly associated with USP10 expression, such as ferroptosis, PI3K/AKT/mTOR, TGF-β, and G2/M checkpoint. In summary, this review outlines the role of USP10 in various forms of cancer, discusses the relevance of USP10 inhibitors in anti-tumor therapies, and highlights the potential function of USP10 in regulating the immune responses of tumors.

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Section: Usp10 Inhibitors and Other Modulators Of Usp10 Activitymentioning

confidence: 99%

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune response

Chen²,

Huang³

et al. 2022

Front. Oncol.

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Research Progress of Caspase in Endometriosis

Yang,

Li,

et al. 2024

Reprod. Sci.

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DUBs in Alzheimer’s disease: mechanisms and therapeutic implications

Qin,

Chen,

Wang

et al. 2024

Cell Death Discov.

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Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by the accumulation of amyloid β protein (Aβ) and the hyper-phosphorylation of the microtubule-associated protein Tau. The ubiquitin-proteasome system (UPS) plays a pivotal role in determining the fate of proteins, and its dysregulation can contribute to the buildup of Aβ and Tau. Deubiquitinating enzymes (DUBs), working in conjunction with activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3), actively maintain the delicate balance of protein homeostasis. DUBs specifically remove ubiquitin tags from proteins marked for degradation, thereby averting their proteasomal breakdown. Several DUBs have demonstrated their capacity to regulate the levels of Aβ and Tau by modulating their degree of ubiquitination, underscoring their potential as therapeutic targets for AD. In this context, we present a comprehensive review of AD-associated DUBs and elucidate their physiological roles. Moreover, we delve into the current advancements in developing inhibitors targeting these DUBs, including the determination of cocrystal structures with their respective targets. Additionally, we assess the therapeutic efficacy of these inhibitors in AD, aiming to establish a theoretical foundation for future AD treatments.

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Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

Cited by 5 publications

References 30 publications

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune response

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune response

Research Progress of Caspase in Endometriosis

DUBs in Alzheimer’s disease: mechanisms and therapeutic implications

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