“…Despite being very water soluble, the SS peptides are remarkably cell permeable, and they are readily taken up and act on all cell types, including endothelial cells, renal and intestinal epithelial cells, myotubes, cardiomyocytes, macrophages and neurons (Zhao et al, 2003;Cho et al, 2007b;Han et al, 2009;Zhu et al, 2010;Andersson et al, 2011;Calkins et al, 2011;Li et al, 2011;Dai et al, 2011a;Gilliam et al, 2012;Kloner et al, 2012;Birk et al, 2013b). The mechanism of cellular uptake for these polar peptides is consistent with diffusion as their uptake is linear and independent of receptor-or transporter-mediated processes (Zhao et al, 2003). Confocal microscopy with fluorescent-labelled analogues suggested that these compounds are localized to mito-chondria (Zhao et al, 2004).…”