Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis

Grafakou, Maria-Eleni; Barda, Christina; Karikas, George A.; Heilmann, Joerg; Skaltsa, Helen

doi:10.1016/j.bioorg.2021.105351

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…During the whole analysis, all extracts and obtained subfractions were continuously monitored and traced down using an NMR metabolomic strategy, which permitted in-detail characterization of their chemical profiles. Furthermore, the 1D and 2D NMR spectra of the BuOH residues were measured (see SM ) [ 15 , 39 , 40 ]. The metabolites were identified using NMR experiments, by comparing the obtained chemical shifts and coupling constant values with standards, as well as with the aid of LC-MS. All candidate structures were compared with those previously published in the literature.…”

Section: Methodsmentioning

confidence: 99%

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

et al. 2022

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This study was designed to evaluate the chemical fingerprints and the antioxidant, anti-inflammatory and hypolipidemic activity of selected Crepis species collected in Greece, namely, C. commutata, C. dioscoridis, C. foetida, C. heldreichiana, C. incana, C. rubra, and Phitosia crocifolia (formerly known as Crepis crocifolia). For the phytochemical analyses, sample measurements were carried out by using nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled with mass spectrometry (LC-MS). Τhe extracts were evaluated both in vitro (radical scavenging activity: DPPH assay and total phenolic content: Folin–Ciocalteu) and in vivo (paw edema reduction and hypolipidemic activity: experimental mouse protocols). Among the tested extracts, C. incana presented the highest gallic acid equivalents (GAE) (0.0834mg/mL) and the highest antioxidant activity (IC50 = 0.07 mg/mL) in vitro, as well as the highest anti-inflammatory activity with 32% edema reduction in vivo. Moreover, in the hypolipidemic protocol, the same extract increased plasma total antioxidant capacity (TAC) by 48.7%, and decreased cholesterol (41.3%) as well as triglycerides (37.2%). According to fractionation of the extract and the phytochemical results, this biological effect may be associated with the rich phenolic composition; caffeoyl tartaric acid derivatives (cichoric and caftaric acid) are regarded as the most prominent bioactive specialized metabolites. The present study contributes to the knowledge regarding the phytochemical and pharmacological profile of Crepis spp.

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Section: Methodsmentioning

confidence: 99%

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

et al. 2022

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“…It is well known that sesquiterpene lactones with this bioactive group have anti-inflammatory and antitumor activities. The electrophilic group can covalently bind to cysteine residues in certain protein targets, thus exerting its corresponding physiological activity 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 . In our previous study, we found that heliangin (HEL), a representative component of heliangolides, elicited sensitivity in hematological tumors, especially in NPM1 mutant AML 24 .…”

Section: Introductionmentioning

confidence: 99%

Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

Yin

Han²,

Hu³

et al. 2023

Acta Pharmaceutica Sinica B

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The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity

Yu¹,

Tang²,

Ke³

et al. 2023

Fitoterapia

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Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis

Cited by 6 publications

References 37 publications

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity

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