First, some mathematical and physical developments of biology and medicine are discussed, including biofield and biological electromagnetics. Second, we research nonlinear biology and biotopology, in which some knots may describe the protein folding. Third, symbolic dynamics of biology and the extensive quantum biology are researched. Fourth, we study the biothermodynamics and entropy. In thermodynamics of pharmacology, the main effects of various drugs are to promote internal interactions in body, and entropy decrease. Further, we introduce the diagnostic space, treatment space and some medicinal vectors, and propose the matrix mechanics of pharmacology. Finally, we research biology, medicine and pharmacology with time sequences. If we master the medication time, this will be able to get the minimum amount of medication, and the drugs can play the maximum treatment effect. If period is accurate, it can determine the time of play, negotiations, attack, etc. But, period of each individual should be change follow age, etc. This is a very valuable research.