Calbindin immunoreactivity in normal human temporal neocortex

Ferrer, Isidre; On, Terpilovskaia; Soriano, Eduardo; Río, José Antonio del; Iráizoz, I.; Fonseca, M.; Guionnet, N.

doi:10.1016/0006-8993(92)90447-h

Cited by 53 publications

(30 citation statements)

References 42 publications

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“…This is in contrast to the pyramidal-like neurons described by Condé et al (1994) in the macaque monkey prefrontal cortex, which were well enough labeled to follow their dendrites for considerable distances. Finally, calcium-binding protein-containing pyramidal neurons are not without precedent, as calretinin is found in a subgroup of Betz cells in the human , parvalbumin is present in layer V pyramidal neurons in primate sensory and motor cortex (Preuss and Kaas, 1996), and in CA1 pyramidal neurons in the dog , and calbindin-containing pyramidal neurons populate layers II and III in many cortical areas in both the monkey and human Ferrer et al, 1992;Hof and Nimchinsky, 1992;Kondo et al, 1994;present study). However, until retrograde labeling or Golgi staining in the human is combined with immunocytochemistry, this question may remain unanswered, since comparable neurons are not observed in the nonhuman primate.…”

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confidence: 87%

“…With the exception of a population of pyramidal neurons that contain calbindin, the neurons that contain these proteins are GABAergic interneurons (Celio, 1990;DeFelipe and Jones, 1992;Résibois and Rogers, 1992). The distribution of cortical neurons containing these calcium-binding proteins has been shown to differ, in certain instances, from area to area in the primate cerebral cortex (Ferrer et al, 1992;Hof and Nimchinsky, 1992;Carmichael and Price, 1994;Condé et al, 1994;Kondo et al, 1994;Hof et al, 1995a). In particular, gradients of in the density of calbindin-immunoreactive neurons has been reported in the visual cortex of the macaque monkey, where the primary visual areas show much lower densities compared to visual association areas located in the parietal and temporal cortex (Kondo et al, 1994).…”

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confidence: 98%

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Neurofilament and calcium-binding proteins in the human cingulate cortex

et al. 1997

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Functional imaging studies of the human brain have suggested the involvement of the cingulate gyrus in a wide variety of affective, cognitive, motor, and sensory functions. These studies highlighted the need for detailed anatomic analyses to delineate its many cortical fields more clearly. In the present study, neurofilament protein, and the calcium-binding proteins parvalbumin, calbindin, and calretinin were used as neurochemical markers to study the differences among areas and subareas in the distributions of particular cell types or neuropil staining patterns. The most rostral parts of the anterior cingulate cortex were marked by a lower density of neurofilament protein-containing neurons, which were virtually restricted to layers V and VI. Immunoreactive layer III neurons, in contrast, were sparse in the anterior cingulate cortex, and reached maximal densities in the posterior cingulate cortex. These neurons were more prevalent in dorsal than in ventral portions of the gyrus. Parvalbumin-immunoreactive neurons generally had the same distribution. Calbindin- and calretinin-immunoreactive nonpyramidal neurons had a more uniform distribution along the gyrus. Calbindin-immunoreactive pyramidal neurons were more abundant anteriorly than posteriorly, and a population of calretinin-immunoreactive pyramidal-like neurons in layer V was found largely in the most anterior and ventral portions of the gyrus. Neuropil labeling with parvalbumin and calbindin was most dense in layer III of the anterior cingulate cortex. In addition, parvalbumin-immunoreactive axonal cartridges were most dense in layer V of area 24a. Calretinin immunoreactivity showed less regional specificity, with the exception of areas 29 and 30. These chemoarchitectonic features may represent cellular reflections of functional specializations in distinct domains of the cingulate cortex.

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confidence: 87%

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confidence: 98%

Neurofilament and calcium-binding proteins in the human cingulate cortex

et al. 1997

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“…As additional examples of this potentially common interneuron defect, a reduction in immunoreactivity against parvalbumin and calcium-binding proteins was also noted in dysplastic cortex from irradiated rats (Roper et al, 1999), from patients with nodular neuronal heterotopia (Hannan et al, 1999), in the hippocampi of experimental models of TLE (Houser et al, 1986;Ribak et al, 1986), and from patients with TLE (Ferrer et al, 1992(Ferrer et al, , 1994DeFelipe et al, 1993;Marco et al, 1996). Because quantitative analysis or staining of serial sections throughout the entire dysplastic area has not been performed in human tissue studies, we cannot infer from histological data alone that these alterations are homogeneous in the dysplastic region.…”

Section: Reduced Gabaergic Inhibition In Focal Cortical Dysplasiamentioning

confidence: 99%

Dysfunction of Synaptic Inhibition in Epilepsy Associated with Focal Cortical Dysplasia

Calcagnotto¹,

Paredes²,

Tihan³

et al. 2005

J. Neurosci.

161

112

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Focal cortical dysplasia (FCD) is a common and important cause of medically intractable epilepsy. In patients with temporal lobe epilepsy and in several animal models, compromised neuronal inhibition, mediated by GABA, contributes to seizure genesis. Although reduction in GABAergic interneuron density has been reported in FCD tissue samples, there is little available information on the resulting physiological changes in synaptic inhibition and the potential contribution of these changes to epileptogenesis in the dysplastic human brain. Using visualized whole-cell patch-clamp recordings from identified neurons in tissue slices obtained from patients with FCD, we demonstrate that GABA A -receptor-mediated inhibition is substantially altered in regions of dysplasia. These alterations include a significant reduction in IPSC frequency and a potentially compensatory decrease in transporter-mediated GABA reuptake function; the latter is marked by a significant increase in the decay-time constant for evoked and spontaneous IPSCs and a lack of effect of the GABA transportinhibitor 1-[2([(diphenylmethylene)imino]oxy)ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride on IPSC kinetics. Immunohistochemical staining revealed a scattering of GABAergic interneurons across dysplastic cortex and striking reductions in GABA transporter expression. Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD.

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“…Nevertheless, because of the inconsistency of the Golgi method and the general difficulties in staining these cells, relatively little is known about their detailed distribution. It has been demonstrated that DBCs are among those neurons consistently labeled when calbindin (CB) immunocytochemistry is performed, enabling their distribution, neurochemical characteristics, and syn-aptic connectivity to be studied in more detail DeFelipe et al, 1990DeFelipe et al, , 1999Ferrer et al, 1992;DeFelipe, 1995, 1997;Elston and GonzalezAlbo, 2003). At present, DBCs are considered as interneurons that contain ␥-aminobutyric acid (GABA) and CB, although certain subpopulations have also been shown to express the calcium binding protein calretinin, and the peptides somatostatin and tachykinin.…”

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confidence: 97%

Double bouquet cell in the human cerebral cortex and a comparison with other mammals

Yáñez

Muñoz

Contreras

et al. 2005

J of Comparative Neurology

120

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Double bouquet cells (DBCs) are neocortical gamma-aminobutyric acid (GABA)ergic interneurons characterized by the vertical bundling of its axon, which are generally termed "bundles" or "horse-tails." Using immunocytochemistry for the calcium binding protein calbindin, we have analyzed the morphology, density, and distribution of DBC horse-tails in different cortical areas of the human cortex (Brodmann's areas 10, 4, 3b, 22, 18, and 17). Although DBC horse-tails were very numerous and regularly distributed in all cortical areas, variations were observed both in terms of morphology and density. We distinguished two major classes of DBC horse-tails: the thicker complex type (type I) that had more axon collaterals; and the simple type (type II). The density of DBC horse-tails was significantly higher in areas 17, 18, 22, and 4 than in areas 3b and 10. Moreover, the proportion of type I and type II DBC horse-tails varied in the cortical areas studied. We also examined the distribution of DBC horse-tails in frontal, parietal, and occipital areas of different mammalian species. We found DBCs to be present in carnivores but not in rodents, lagomorphs, or artiodactyls. In carnivores, relatively few DBC horse-tails can be identified and they were generally found in the occipital cortex. Therefore, there is significant variability in the morphology and distribution of DBC horse-tails in different species and cortical areas. We conclude that, although these interneurons may be an important element in the organization of cortical microcolumns in primates, this is not the case in other mammalian species.

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Calbindin immunoreactivity in normal human temporal neocortex

Cited by 53 publications

References 42 publications

Neurofilament and calcium-binding proteins in the human cingulate cortex

Neurofilament and calcium-binding proteins in the human cingulate cortex

Dysfunction of Synaptic Inhibition in Epilepsy Associated with Focal Cortical Dysplasia

Double bouquet cell in the human cerebral cortex and a comparison with other mammals

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