Calcaneal Quantitative Ultrasonography and Urinary Retinol-Binding Protein in Antiretroviral-Treated Patients With Human Immunodeficiency Virus in Uganda: A Pilot Study

Costa, Cecília; Scabini, Silvia; Kaimal, Arvind; Kasozi, William; Cusato, Jessica; Kafufu, Bosco; Borderi, Marco; Mwaka, Erisa; Perri, Giovanni Di; Lamorde, Mohammed; Calcagno, Andrea; Castelnuovo, Barbara

doi:10.1093/infdis/jiaa088

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The changes of RBP content suggest the pathological changes of renal tubules and glomeruli. Under the action of induction factors, RBP can stimulate oxidative stress in the body and increase the damage of oxygen free radicals to the vascular endothelium[ 24 - 26 ].…”

Section: Discussionmentioning

confidence: 99%

Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

Lin¹,

Dai²,

Zhao³

et al. 2023

World J Diabetes

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BACKGROUND Diabetic nephropathy (DN) is a microangiopathy of type 2 diabetes mellitus (T2DM), which can damage the kidney through various ways and mechanisms due to the nature of the disease, involving the renal interstitium and glomeruli. However, in the early stage of the disease, patients only showed kidney volume increase and glomerular hyperthyroidism, and typical symptoms that are difficult to arouse individual attention were noticed. AIM To observe the expression of serum retinol-binding protein (RBP) and urinary N-acetyl-β-D-glucosaminidase (NAG) in patients with DN, and to analyze their value in disease prediction, so as to provide new targets for early diagnosis and treatment of DN. METHODS The baseline data of 50 T2DM patients treated in our hospital between January 2021 and December 2022 were retrospectively reviewed and included in group A. The baseline data of 50 patients with type 2 DN admitted to our hospital during the same period were collected and included in group B. The baseline data and serum RBP and urine NAG expression were compared between the two groups to analyze their value in the early prediction of DN. RESULTS There was no significant difference in age, gender, duration of diabetes, combined hyperlipidemia and combined hypertension between the two groups ( P > 0.05); the expression of urinary NAG and serum RBP in group B was higher than that in group A, and the difference was statistically significant ( P < 0.05); a multiple logistic regression model was established, and the results showed that urinary NAG and serum RBP were related to the presence or absence of injury in diabetic patients, and overexpression of urinary NAG and serum RBP may be risk factors for renal injury in T2DM patients (OR > 1, P < 0.05); receiver operating curve curve was plotted, and the results showed that the area under the curve of urinary NAG and serum RBP expression alone and in combination for predicting DN was > 0.80, and the predictive value was satisfactory; bivariate Spearman linear correlation analysis showed that there was a positive correlation between urinary NAG and serum RBP expression in patients with DN ( r = 0.566, P = 0.000). CONCLUSION The increased expression of urinary NAG and serum RBP may be the risk factors leading to the progression of T2DM to DN. The possibility of DN can be considered in patients with urinary NAG and serum RBP overexpression by examining the expression of urinary NAG and serum RBP in patients with T2DM in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

Lin¹,

Dai²,

Zhao³

et al. 2023

World J Diabetes

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Evaluating the associations of adult heel BMD with birth weight and growth parameters at age 10 in UK Biobank cohort

Yang

Cheng

et al. 2021

Bone

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Longitudinal patients’ cohorts for impactful research and HIV care at the Infectious Diseases Institute

Castelnuovo¹,

Kamya²,

Parkes-Ratanshi³

et al. 2022

Afr H. Sci.

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Introduction: Observational studies provide important evidence supporting the feasibility and effectiveness of health interventions. The 20-year-old Infectious Diseases Institute (IDI) established to respond to infectious diseases, specifically HIV/AIDS, invested in the set-up of longitudinal cohorts. In this paper we discuss the results of these cohorts and their impact on the response to the HIV pandemic in Uganda. Methods: IDI invested in experienced system developers, clinic and laboratory capacity to create the infrastructure to host longitudinal cohorts. Several cohorts were created, including patients initiated and followed up on ART, specialized cohorts (e.g. TB co-infection) and long-term cohorts with patients on ART for over 10 years and aged 60 and above. These cohorts function as platforms for sub-studies, attracting collaborators and students. Results: Data from the IDI cohorts contributed evidence to ART programs on when to start, which drugs to use, how to best monitor and which models of care to implement. Sub-studies contributed to management of opportunistic infections, understanding immunological response and the emerging complications of non-communicable diseases. Conclusion: Cohorts provide a platform for clinical care, training, and research to inform strategic responses and put Makerere University at the center of the response to the HIV pandemic in the region. Keywords: Longitudinal Cohorts; Uganda; HIV.

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Calcaneal Quantitative Ultrasonography and Urinary Retinol-Binding Protein in Antiretroviral-Treated Patients With Human Immunodeficiency Virus in Uganda: A Pilot Study

Cited by 3 publications

References 41 publications

Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy

Evaluating the associations of adult heel BMD with birth weight and growth parameters at age 10 in UK Biobank cohort

Longitudinal patients’ cohorts for impactful research and HIV care at the Infectious Diseases Institute

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