Calcaneal quantitative ultrasound has a role in out ruling low bone mineral density in axial spondyloarthropathy

Fitzgerald, Gillian; Anachebe, Tochukwu; McCarroll, Kevin; O’Shea, Finbar

doi:10.1007/s10067-019-04876-9

Cited by 8 publications

(14 citation statements)

References 25 publications

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“…The accuracy of the QUS T-score in identifying osteoporosis at the lumbar spine (AUC = 0.793) was higher than that in identifying osteoporosis at the femoral neck (AUC = 0.706) and either site (AUC = 0.723). Previous study has also demonstrated the AUC of the QUS T-score in identifying osteoporosis at the lumbar spine is higher than that at the femoral neck 23 . We found a moderate correlation between the QUS T-score and DXA T-score at both the femoral neck and spine.…”

Section: Discussionmentioning

confidence: 89%

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Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients

Chanprasertpinyo

Punsawad

Sukkriang

et al. 2021

Preprint

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IntroductionOsteoporosis is a prevalent comorbidity in patients with COPD that is usually underrecognized and hence undertreated. Compared to the gold standard dual-energy X-ray absorptiometry (DXA), calcaneus quantitative ultrasound (QUS) is less expensive, more portable, and more accessible, especially in less developed countries. The aim of this study was to investigate the ability of calcaneus QUS to detect osteoporosis in patients with COPD.MethodsThis cross-sectional study enrolled 67 males older than 50 years with clinically stable COPD. DXA scans of the lumbar spine (L2-4) and femoral neck were performed. QUS of the right calcaneus (AOS-100) were used to assess the broadband ultrasound attenuation (BUA), speed of sound (SOS), osteo sono-assessment index (OSI), and T-score. When the T-score was ≤ − 2.5, osteoporosis was diagnosed by both DXA and QUS.ResultsForty-eight patients (71.6%) had DXA T-scores ≤ − 2.5 at either the lumbar spine or femoral neck. All QUS parameters (BUA, SOS, OSI, and T-score) could discriminate DXA-determined osteoporosis (the area under the curve varied from 0.64 to 0.83). The QUS T-score was significantly moderately correlated with the DXA T-score at both the femoral neck (r = 0.62) and lumbar spine (r = 0.53). The sensitivity and specificity of QUS in identifying osteoporosis were 10.4% and 94.7%, respectively. The positive and negative predictive values were 83.3% and 29.5%, respectively.ConclusionThe calcaneus QUS T-score had the ability to identify osteoporosis with an acceptable level of accuracy. However, the sensitivity and specificity of the QUS T-score were not sufficiently high to serve as an alternative diagnostic tool to DXA.

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Section: Discussionmentioning

confidence: 89%

“…Many studies have demonstrated that calcaneus QUS may be used as a prescreening tool before DXA 10,22,23 . With a device-speci c upper threshold of 90% sensitivity and a lower threshold of 90% speci city, individuals who have either a high or low likelihood of osteoporosis can be identi ed 9,30 .…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients

Chanprasertpinyo

Punsawad

Sukkriang

et al. 2021

Preprint

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“…This could be due to the sex of the patients, since women with Parkinson’s disease present worse bone quality than healthy women and these differences cannot be seen in men. To determine these differences, the QUS technique for bone determination of the calcaneus is shown to be effective, which together with the clinical characteristics of patients with Parkinson’s disease and its correlation with DXA densitometry [ 25 , 53 , 54 , 55 ], could make it a particularly adequate technique for determination of bone quality in these types of patients.…”

Section: Discussionmentioning

confidence: 99%

Bone Quality in Patients with Parkinson’s Disease Determined by Quantitative Ultrasound (QUS) of the Calcaneus: Influence of Sex Differences

Caplliure-Llopis

Escrivá

Navarro-Illana

et al. 2022

IJERPH

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(1) Background: Parkinson’s disease (PD) is a relatively common neurodegenerative disease in elderly individuals, with a high risk of falls. There is abundant literature on the relationship between PD and osteoporosis. The aim of this study is to describe the bone quality of a population with PD by calcaneal ultrasound and to compare it with a healthy control, assessing the influence of possible sex differences. (2) Methods: 21 patients diagnosed with PD were recruited. The control group was composed of 30 healthy individuals with similar sociodemographic characteristics. The bone quality of all participants was assessed using calcaneal quantitative ultrasound (QUS). The parameters recorded were broadband ultrasound attenuation (BUA, in decibels per megahertz), imaging speed of sound (SOS, in meters per second), stiffness index (SI) and T-score of each participant. Bone mineral density (BMD) was estimated using the equation BMD = 0.002592 × (BUA + SOS) − 3.687 (g/cm2). (3) Results: significant differences were observed between the healthy control and the PD group: the T-score was lower in the PD group (p < 0.05) and SOS was higher in Parkinson’s disease patients (p < 0.05), while 28.6% of the PD patients were osteoporotic with T-score values lower than −1.5 compared to 16.7% of osteoporotic individuals in the control group (p < 0.01). Regarding the sex, there were significant differences (p < 0.05) between the females of the PD group vs. control group, showing a significant difference in the SI (71.4 ± 14.7 vs. 87.8 ± 12), T-score (−2.19 ± 1.1 vs. −0.15 ± 0.8), BUA (104.5 ± 13 vs. 116 ± 10.6) and BMD (0.49 ± 0.09 vs. 0.60 ± 0.08), with no difference in the comparison between the male groups; and the comparison between both sexes in T-score only showed significant differences for the PD group (p < 0.05), with worse bone quality in women. (4) Conclusions: this study shows poorer bone quality in female patients with PD, who have a higher percentage of osteoporosis than healthy patients. The QUS technique of the calcaneus seems adequate for these determinations in patients with Parkinson’s disease.

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“…It is indicated that the peripheral QUS technique is capable of predicting people with low bone density at the axial skeleton as measured by DXA [55,56]. And the calcaneus QUS had been confirmed as effective methods in fractures discrimination [12,13,57,58]. So far, the fractures discriminative ability of radius QUS is still controversial.…”

Section: Discussionmentioning

confidence: 99%

Fragility fracture discriminative ability of radius quantitative ultrasound: a systematic review and meta-analysis

Luo

et al. 2020

Osteoporos Int

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The fragility fracture discriminative ability of radius quantitative ultrasound (QUS) was evaluated in a systematic review of 13 studies, including 16,681 individuals and 1296 fractures. The radial speed of sound (SOS) per standard deviation (SD) decrease contributed to an increased risk of total and hip fracture by 32% and 66% in women. Osteoporotic fracture, as a devastating consequence of osteoporosis, brings severe socioeconomic burden. The availability of dual-energy X-ray absorptiometry (DXA), as the gold standard of diagnosis, was quite limited in remote areas. Radius QUS measured by SOS shows potential in fracture discriminative ability where DXA equipment is not available. This study aimed to provide a comprehensive evaluation of the association between radius QUS and fracture risk. A detailed article search was carried out on PubMed, EMBASE, Cochrane Libraries, CNKI, Wan-Fang database, VIP, and SinoMed for studies published between January 1980 and February 2020. We determined the estimated relative risk (RR) for fracture per each radial SOS SD decrease. A meta-analysis of studies was performed under the random-effects model. A total of 16,681 individuals were included in this review. Among the participants, 5892 were male and 10,789 were female. A total of 1296 cases of fragility fracture were included. With each SD decrease in radial SOS, the risk of overall fragility fracture and hip fracture was increased by 21% and 55%, respectively. Particularly, the risk was increased by 32% and 66% for women. The association was even stronger for postmenopausal women. Radius QUS showed great potential as an effective tool for fracture risk evaluation, especially for women.

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Calcaneal quantitative ultrasound has a role in out ruling low bone mineral density in axial spondyloarthropathy

Cited by 8 publications

References 25 publications

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients

Bone Quality in Patients with Parkinson’s Disease Determined by Quantitative Ultrasound (QUS) of the Calcaneus: Influence of Sex Differences

Fragility fracture discriminative ability of radius quantitative ultrasound: a systematic review and meta-analysis

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Calcaneal quantitative ultrasound has a role in out ruling low bone mineral density in axial spondyloarthropathy

Cited by 8 publications

References 25 publications

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in&nbsp;COPD Patients

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in&nbsp;COPD Patients

Bone Quality in Patients with Parkinson’s Disease Determined by Quantitative Ultrasound (QUS) of the Calcaneus: Influence of Sex Differences

Fragility fracture discriminative ability of radius quantitative ultrasound: a systematic review and meta-analysis

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Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients

Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA In the Ability to Detect Osteoporosis in COPD Patients