Calcific uremic arteriolopathy

Olaoye, Olanrewaju A; Koratala, Abhilash

doi:10.1093/omcr/omx055

Cited by 7 publications

(7 citation statements)

References 3 publications

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“…The authors also reported that STS possesses vasodilatory and antioxidant properties. Their findings were in agreement with previous reports that suggested that STS could combine with insoluble tissue calcium salts to form calcium thiosulfate, a salt that can later be dialyzed [ 11 , 58 , 59 , 60 ]. Thus, treatment of calciphylaxis with STS is partly due to its antioxidant and calcium-chelating and vasodilatory properties.…”

Section: Clinical Usefulness Of Stssupporting

confidence: 92%

“…In a recent experimental rat model of hyperoxaluria and renal injury, 0.4 g/kg dose of STS treatment scavenged reactive oxygen species (ROS) in a dose-dependent manner, mitigated cellular hydrogen peroxide levels, and maintained superoxide dismutase activity [ 6 ]. It is important to note that thiosulfate has two lone electron pairs: one at the single bonded sulfur moiety of the disulfide bond and the other at the single bonded oxygen [ 60 ]. This characteristic allows thiosulfate to act as an effective antioxidant by donating electrons to unpaired damaging electrons associated with mitochondrial ROS [ 37 , 63 , 64 ].…”

Section: Potential Clinical Applications Of Stsmentioning

confidence: 99%

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Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Zhang

Dugbartey

Juriasingani

et al. 2021

IJMS

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Thiosulfate in the form of sodium thiosulfate (STS) is a major oxidation product of hydrogen sulfide (H2S), an endogenous signaling molecule and the third member of the gasotransmitter family. STS is currently used in the clinical treatment of acute cyanide poisoning, cisplatin toxicities in cancer therapy, and calciphylaxis in dialysis patients. Burgeoning evidence show that STS has antioxidant and anti-inflammatory properties, making it a potential therapeutic candidate molecule that can target multiple molecular pathways in various diseases and drug-induced toxicities. This review discusses the biochemical and molecular pathways in the generation of STS from H2S, its clinical usefulness, and potential clinical applications, as well as the molecular mechanisms underlying these clinical applications and a future perspective in kidney transplantation.

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Section: Clinical Usefulness Of Stssupporting

confidence: 92%

Section: Potential Clinical Applications Of Stsmentioning

confidence: 99%

Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Zhang

Dugbartey

Juriasingani

et al. 2021

IJMS

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“…A total of 50 cases of penile calciphylaxis have been reported in the English literature ( Table 1 ) [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. The average age was 54.5 years (range 32 to 81).…”

Section: Discussionmentioning

confidence: 99%

Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature

et al. 2018

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AbstractPenile calciphylaxis is a rare cause of penile gangrene that presents in patients with end-stage renal disease. The rates of comorbidity and mortality of penile calciphylaxis are extremely high. Unlike other penile gangrene, such as Fournier’s gangrene, the benefit of aggressive surgical therapy is controversial. Here we present a case of penile calciphylaxis in a 43-year-old man with end-stage renal disease on hemodialysis. He received total penectomy but died due to multisystem complications 2 weeks after surgery. We review the literature on the management options and outcomes in patients with penile calciphylaxis.

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“…In addition to passive calcium deposition in degenerative tissue, active ossification is seen in vascular calcification in the form of endochondral and intramembranous (non-endochondral) ossifications [6]. Calcific uremic arteriolopathy is another form of calcification seen in hemodialysis [7]. It is hypothesized that vascular smooth muscle responds to the increase of serum phosphate by mineralizing it with calcium in the extracellular matrix.…”

Section: Pathogenesis and Pathophysiologymentioning

confidence: 99%

Subclavian Artery Calcification: A Narrative Review

Ahmed¹,

Parwani²,

Mahawar³

et al. 2022

Cureus

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Subclavian artery calcification (SAC) affects 2% of the population and presents a serious risk of developing into subclavian steal syndrome (SSS). Risk factors for plaque formation of the subclavian artery include diabetes, hypertension, and smoking. While SAC generally presents as asymptomatic, symptoms in severe cases may include numbness, pain at rest, and ischemic gangrene. Patients with severe SSS are at high risk of developing neurological symptoms as a result of vertebrobasilar insufficiency affecting posterior cerebral perfusion. On physical examination, SSS is preliminarily diagnosed from bilateral inter-arm systolic blood pressure discrepancy (>10 mmHg), which can be further confirmed with vascular imaging. Duplex ultrasound (DUS) is a cost-effective and non-invasive baseline technique for visualizing luminal stenosis and quantifying peak systolic velocity (PSV). Computed tomography angiography (CTA) provides high-quality, fast, three-dimensional (3D) imaging at the cost of introducing nephrotoxic contrast agents. Magnetic resonance angiography (MRA) is the safest 3D imaging modality, without the use of X-rays and contrast agents, that is useful in assessing plaque characteristics and degree of stenosis. DUS-assisted digital subtraction angiography (DSA) remains the gold standard for grading the degree of stenosis in the subclavian artery and determining the distance between the puncture site and lesion, which can be carried out in a combined procedure with endovascular management strategies. The fundamental treatment options are surgical and endovascular intervention. Endovascular treatment options include percutaneous transluminal angiography (PTA) for recanalization of the stenosed vessel and permanent balloon stenting to prevent collapse after PTA. Overall, the benefits of endovascular management encompass faster recovery, lower stenosis recurrence rate, and lower incidence of complications, making it the treatment of choice in low-risk patients. Surgical interventions, although more complex, are considered gold-standard treatment options.

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Calcific uremic arteriolopathy

Cited by 7 publications

References 3 publications

Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature

Subclavian Artery Calcification: A Narrative Review

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