Calcification of Hydrophilic Acrylic Intraocular Lenses With a Hydrophobic Surface: Laboratory Analysis of 6 Cases

Gartaganis, Sotirios P.; Prahs, Philipp; Lazari, Eftichia D.; Gartaganis, Panos S; Helbig, Horst; Koutsoukos, Petros G.

doi:10.1016/j.ajo.2016.04.018

Cited by 48 publications

(54 citation statements)

References 20 publications

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“…Opacification of hydrophilic IOLs with hydrophobic coating was first described in 2012, and several case reports have been published since then. [10][11][12][13][14] In this cohort, we evaluated 154 eyes implanted with LS-502-1 and found an opacification prevalence of 53.3% (n = 90). To the best of our knowledge, this is not only the largest case series of opacified hydrophilic/hydrophobic IOLs, but also the highest opacification rate ever described for any type of IOL.…”

Section: Discussionmentioning

confidence: 99%

“…7 Variables such as manufacturing and storage methods, intraocular solutions, use of surgical adjuvants and patient comorbidities have been tentatively linked to this occurrence. 8,9 In order to reduce the opacification rate of these types of IOLs, several strategies have been attempted, such as surface-modification of the hydrophilic acrylic material with a hydrophobic coating 10 as in the Lentis LS-502-1 (Oculentis ® GmbH, Berlin, Germany). This is a foldable, one-piece IOL, composed of a hydrophilic acrylic polymer with a hydrophobic coating.…”

Section: Several Cases Of Iol Opacification Of Various Materials Havementioning

confidence: 99%

“…This is a foldable, one-piece IOL, composed of a hydrophilic acrylic polymer with a hydrophobic coating. Despite this design revision, several cases of opacification of this IOL have been observed, [10][11][12][13] ultimately warranting its explantation in some patients. In our department, the LS-502-1 IOL was implanted between 2010 and 2012 in over 350 patients.…”

Section: Several Cases Of Iol Opacification Of Various Materials Havementioning

confidence: 99%

“…In order to reduce the opacification rate of these types of IOLs, several strategies have been attempted, such as surface-modification of the hydrophilic acrylic material with a hydrophobic coating 10 as in the Lentis LS-502-1 (Oculentis ® GmbH, Berlin, Germany). This is a foldable, one-piece IOL, composed of a hydrophilic acrylic polymer with a hydrophobic coating.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Large-scale opacification of a hydrophilic/hydrophobic intraocular lens

Costa

Bompastor-Ramos

Marques

et al. 2019

European Journal of Ophthalmology

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Purpose: To determine the prevalence and risk factors related to the opacification of the LS-502-1 intraocular lens. Methods: Cross-sectional study including patients submitted to cataract surgery between January 2010 and March 2012, with implantation of the LS-502-1 intraocular lens. Past medical history was registered and a complete ophthalmologic evaluation, that included best-corrected visual acuity, slit-lamp examination and fundoscopy, was performed. Anterior segment photographs were taken whenever intraocular lens opacification was present. Results: One hundred and sixty-nine eyes of 154 patients were included, mean age 78.5 ± 7.9 years. The average follow-up after intraocular lens implantation was 65.6 ± 10.0 months. Intraocular lens opacification was seen in 53.3% (n = 90) and presented as one of four different patterns: peripheral (15.6%, n = 14), central (4.4%, n = 4), diffuse (71.1%, n = 64) and superficial white deposits (8.9%, n = 8). There was no statistically significant association with systemic or ophthalmic conditions. In patients with bilateral implantation, intraocular lens opacification in one eye was significantly related to intraocular lens opacification in the fellow eye. A significant variability in opacification was found across intraocular lens serial numbers: the odds ratio for opacification in intraocular lens with serial number beginning with 200003 was 6.0 when comparing with the remaining lenses. Conclusion: The opacification prevalence of the LS-502-1 intraocular lens was 53.3%, which is the highest ever described for any intraocular lens model. Our results suggest that this occurrence is secondary to an interaction between unknown patient variables and problems related to intraocular lens manufacturing and storage procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Several Cases Of Iol Opacification Of Various Materials Havementioning

confidence: 99%

Section: Several Cases Of Iol Opacification Of Various Materials Havementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Large-scale opacification of a hydrophilic/hydrophobic intraocular lens

Costa

Bompastor-Ramos

Marques

et al. 2019

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Case series of IOL opacification, especially after Descemet stripping endothelial keratoplasty and Descemet's stripping automated endothelial keratoplasty have also been reported (6,7). Moreover, IOL opacification due to calcified deposits has also been described in hydrophilic IOLs, as well as in hydrophilic IOLs with hydrophobic surface, presumably caused by hydration of the IOL or the presence of a manufacturing IOL defect (8)(9)(10). However, opacification of a hydrophobic multifocal IOL has never been reported before.…”

Section: Discussionmentioning

confidence: 99%