Calcification of the linea aspera: A systematic narrative review

Low, Samantha; Toms, Andoni P.

doi:10.1016/j.ejro.2018.12.002

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…e cranial most portion gives attachment to the gluteus maximus and is separately termed as gluteal tuberosity. [4] Calcific tendinitis is a condition of uncertain etiology wherein a particular form of calcium (apatite) deposition within the tendon incites inflammation. e various stages include pre-calcification, calcific, and post-calcific phases.…”

Section: Discussionmentioning

confidence: 99%

“…e proposed reasons include a combination of enthesitis (secondary to traction or seronegative arthropathy) and calcific tendinitis resulting in cortical irregularity, enthesophyte formation, and marrow edema. [4] e other possibility is due to inflammation and hypervascularity of large muscle mass incited by crystal deposition resulting in adjacent osseous resorption accompanied by strong mechanical forces together causing cortical and marrow changes. [6] Similar osseous changes have been described in humerus at tuberosities and at pectoralis major attachment.…”

Section: Discussionmentioning

confidence: 99%

“…Cortical erosions and focal sclerosis can be documented. Small soft-tissue components and inflammation are often missed on CT. [3,4,[6][7][8] MR offers advantages in evaluating the inflammation, associated soft tissue, and marrow edema. [3,6] Paradoxically, the presence of marrow edema on MR directs to a more sinister process such as neoplasm, and often a combination of imaging along with detailed clinical information is necessary to avoid invasive procedures.…”

Section: Discussionmentioning

confidence: 99%

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Imaging in calcific tendinitis of linea aspera: A case report and review of literature

Patil

Samson

2021

IJMSR

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Linea aspera, the osseous ridge in the upper posterior femur, offers attachment to multiple muscles and tendons forming a fibroentheses. Deposition of calcium hydroxyapatite crystal and subsequent inflammation leads to tendinitis and calcification. This process is relatively rare at linea aspera but is a cause of pain and movement restriction. Radiographs are many times misleading as the linea aspera irregularity and calcific proliferation mimic irregular periosteal reaction associated with surface bone malignancies. MRI and CT are complementary and problem-solving. Awareness of the specific location and imaging features aids in the diagnosis of this condition which is frequently managed by a conservative approach avoiding the need for invasive procedures like biopsy for diagnosis. This case report depicts classical imaging features of this entity on multiple modalities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imaging in calcific tendinitis of linea aspera: A case report and review of literature

Patil

Samson

2021

IJMSR

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“…[ 67 ] It is defined by calcium crystal deposition (HAp) in tendons predominantly occurring in shoulder region with prevalence of 3% of adult population of age between 30 and 50 years old. [ 68 ] In calcific tendonitis similarly to other pathologic calcifications such as in cardiovascular or renal systems, MVs are the main site of mineralization. [ 67,69 ] The role of MVs is to provide enzymes required for regulation of extravesicular internal tissue composition, which several studies showed that they contain necessary proteins for ion transport across membrane including annexin V [ 70 ] and proteolipids.…”

Section: Phase Composition and Structural Analysismentioning

confidence: 99%

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding

Radvar

Griffanti

Tsolaki

et al. 2021

Advanced NanoBiomed Research

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Physiological calcification plays an essential part in the development of the skeleton and teeth; however, the occurrence of calcification in soft tissues such as the brain, heart, and kidneys associates with health impacts, creating a massive social and economic burden. The current paradigm for pathological calcification focuses on the biological factors responsible for bone‐like mineralization, including osteoblast‐like cells and proteins inducing nucleation and crystal growth. However, the exact mechanism responsible for calcification remains unknown. Toward this goal, this review dissects the current understanding of structure–function relationships and physico‐chemical properties of pathologic calcification from a materials science point of view. We will discuss a range of potential mechanisms of pathological calcification, with the purpose of identifying universal mechanistic pathways that occur across multiple organs/tissues at multiple length scales. The possible effect of extracellular components in signaling and templating mineralization, as well as the role of intrinsically disordered proteins in calcification, is reviewed. The state‐of‐the‐art in vitro models and strategies that can recreate the highly dynamic environment of calcification are identified.

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“…Calcific enthesopathy represents a common pitfall in the evaluation of RC tendons [ 50 , 51 ]. This condition is the result of a degenerative process, which appears more often with aging and can be idiopathic or associated with seronegative arthropathies or chronic traction injuries [ 52 ]. Occasionally, in calcific enthesopathy, deposition of calcium pyrophosphate may be detected.…”

Section: Common Pitfallsmentioning

confidence: 99%

Imaging of calcific tendinopathy around the shoulder: usual and unusual presentations and common pitfalls

et al. 2020

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Rotator cuff calcific tendinopathy (RCCT) is a very common condition, characterized by calcium deposition over fibrocartilaginous metaplasia of tenocytes, mainly occurring in the supraspinatus tendon. RCCT has a typical imaging presentation: in most cases, calcific deposits appear as a dense opacity around the humeral head on conventional radiography, as hyperechoic foci with or without acoustic shadow at ultrasound and as a signal void at magnetic resonance imaging. However, radiologists have to keep in mind the possible unusual presentations of RCCT and the key imaging features to correctly differentiate RCCT from other RC conditions, such as calcific enthesopathy or RC tears. Other presentations of RCCT to be considered are intrabursal, intraosseous, and intramuscular migration of calcific deposits that may mimic infectious processes or malignancies. While intrabursal and intraosseous migration are quite common, intramuscular migration is an unusual evolution of RCCT. It is important also to know atypical regions affected by calcific tendinopathy as biceps brachii, pectoralis major, and deltoid tendons. Unusual presentations of RCCT may lead to diagnostic challenge and mistakes. The aim of this review is to illustrate the usual and unusual imaging findings of RCCT that radiologists should know to reach the correct diagnosis and to exclude other entities with the purpose of preventing further unnecessary imaging examinations or interventional procedures.

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Calcification of the linea aspera: A systematic narrative review

Cited by 5 publications

References 20 publications

Imaging in calcific tendinitis of linea aspera: A case report and review of literature

Imaging in calcific tendinitis of linea aspera: A case report and review of literature

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding

Imaging of calcific tendinopathy around the shoulder: usual and unusual presentations and common pitfalls

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