Calcified aldosterone-producing adrenocortical adenoma

Jelić, Tomislav; Triest, William E.; Sheils, John F.; Porter, David A.; Cherry, Daniel A.; Baltaro, Richard J.; Sheils, W. J.; Driscoll, Henry K.; Solanki, Haresh P.; Molina, R.; Molina, Louis; Chertow, Bruce S.

doi:10.1016/0899-7071(95)00092-5

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…When the tumor is very large, it is difficult to distinguish adenoma from carcinoma. This distinction is important because of the dismal prognosis of carcinomas, different treatments and different surgical approaches 13 . Compared to adenomas, carcinomas are usually larger, can occur at any age including in children (adenomas usually occur in adults), they have multiple and bleeding surfaces on gross examination, are frequently calcified, generally secrete more than one steroid hormone, are not visualized on 131 I‐iodocholesterol scans, and might cause more pronounced hypokalemia 14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…This distinction is important because of the dismal prognosis of carcinomas, different treatments and different surgical approaches. 13 Compared to adenomas, carcinomas are usually larger, can occur at any age including in children (adenomas usually occur in adults), they have multiple and bleeding surfaces on gross examination, are frequently cal-cified, generally secrete more than one steroid hormone, are not visualized on 131 I-iodocholesterol scans, and might cause more pronounced hypokalemia. 14,15 Microscopic examination of adrenocortical carcinomas might show a high mitotic rate, pleomorphism, vascular and capsular invasion, tumor cell necrosis and broad fibrous bands traversing the tumor, 12,16 but large adenomas might show hemorrhage, cystic degeneration and calcification.…”

Section: Discussionmentioning

confidence: 99%

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Non‐functional adrenocortical adenoma with extensive degeneration

Masugi

Kameyama

Aiba

et al. 2003

Pathology International

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We report a case of non-functional adrenocortical adenoma of 5.5 x 5.5 x 3.2 cm in size that had an unusual histopathological appearance in two respects. First, the tumor contained small adipose foci with osteogenesis and was suspected of being a myelolipoma based on its appearance on computerized tomography (CT) and magnetic resonance imaging. However, pathologically, the fat element was seen focally and was not accompanied by hematopoietic cells, and the diagnosis of myelolipoma was abandoned. Second, the tumor was suspected of being an adrenal carcinoma based on its appearance on CT scans and showed extensive degeneration: fibrosis, hemorrhage, loss of parenchyma and moderate atypism of the tumor cells. However, as the architecture of the tumor cells was non-diffuse and there were no necrotic foci or mitoses, and vascular or capsular invasion were not present, the tumor was concluded to be an adrenocortical adenoma rather than a carcinoma. We diagnosed the tumor as a non-functional adrenocortical adenoma with extensive degeneration as the extensive areas of fibrosis were particularly remarkable. Furthermore, the extensive areas of degeneration might have been caused not only by an ischemic effect but also by low hormone levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non‐functional adrenocortical adenoma with extensive degeneration

Masugi

Kameyama

Aiba

et al. 2003

Pathology International

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Large Degenerated Adrenal Adenomas: Radiologic-Pathologic Correlation

Newhouse¹,

Heffess²,

Wagner³

et al. 1999

Radiology

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A subgroup of adrenal adenomas are larger, more heterogeneous, and more frequently calcified than those with the usual imaging findings. Central necrosis, hemorrhage, or both are responsible for many of the imaging features. Differentiation of these lesions from other large adrenal masses, including adrenal carcinoma, cannot be made by means of imaging alone; resection is required for the definitive diagnosis.

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Calcified aldosterone-producing adrenocortical adenoma

Cited by 2 publications

References 12 publications

Non‐functional adrenocortical adenoma with extensive degeneration

Non‐functional adrenocortical adenoma with extensive degeneration

Large Degenerated Adrenal Adenomas: Radiologic-Pathologic Correlation

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