Calcified amorphous tumor presenting with rapid growth in the ascending aorta

Yoshida, Soshi; Koizumi, Shigeki; Hara, Shigeo; Tsubota, Hideki; Koyama, Tadaaki

doi:10.1016/j.jvscit.2020.08.006

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Notable in our case was that we observed not only a rapid growth but also a rapid shrinkage of CAT after the infarctions. Also notable was that, while the patients were on hemodialysis in most cases of rapidly growing CAT [ 6 , 7 , 9 ], our patient was normal in renal function.…”

Section: Discussionmentioning

confidence: 80%

“…As a mechanism underlying infarction, CAT itself or the fibrin on the mass surface is considered to be the source of clogging [ 10 ]. Meanwhile, CAT can grow rapidly from 6 weeks to 1 year [ 6 – 9 ]. In our case, CAT grew in 7 months and caused multiple infarctions.…”

Section: Discussionmentioning

confidence: 99%

“…However, no case has been reported where CAT rapidly grew AND diminished in a short period of time. In addition, in most cases of rapidly growing CAT, the patients were on hemodialysis [ 6 , 7 , 9 ]; few, if any, patients with normal renal function have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report

et al. 2022

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Background Calcified amorphous tumor (CAT) of the heart is a rare non-neoplastic intracardiac mass, a calcium deposition surrounded by amorphous fibrous tissue, and possibly causes cerebral embolism. Even rarer is CAT associated with infection, and no CAT with antecedent infection has been reported to our knowledge. In addition, although some CAT in patients on hemodialysis has been reported to grow rapidly, no case has been reported on CAT that grew and diminished rapidly in a short period of time. Here, we report the case of an 82-year-old Japanese woman with normal renal function who developed multiple cerebral infarctions due to CAT that grew rapidly, associated with inflammation from an antecedent infection, and diminished rapidly by detachment of fibrin on the mass surface and antithrombotic drugs. Case presentation The patient developed fever after dental treatment and found musical hallucination on the left ear worsened in degree and frequency. In a nearby clinic, she was treated with antibiotics, and her body temperature turned to normal in approximately 1 month. She presented to our hospital for workup on the worsened musical hallucination. Magnetic resonance imaging (MRI) showed multiple cerebral infarctions, and transthoracic echocardiography (TTE) revealed an immobile hyperechoic mass with an acoustic shadow arising from a posterior cusp of the mitral valve. CAT was suspected and treated with apixaban and aspirin. Follow-up MRI and TTE showed newly developed multiple cerebral infarctions and rapidly diminished CAT. Cardiac surgery was performed to resect the CAT. The pathological findings showed calcifications surrounded by amorphous fibrous tissue including fibrin, indicating CAT. The patient’s symptoms improved and no cerebral infarctions recurred in 4 months follow-up. Conclusion Inflammation from an antecedent infection can cause CAT to grow rapidly. Fibrous tissue including fibrin may attach to the surface of CAT, resulting in multiple cerebral infarctions. Fibrous tissue may detach and disappear by antithrombotic drugs, leading to a rapid diminishment of CAT in size.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report

et al. 2022

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“…While the pathogenesis of CAT is poorly understood, it likely involves hypercoagulability resulting in an organised thrombus, with or without a disturbance in calcium-phosphorus metabolism, often in the setting of renal disease 2 7. While typical locations include any cardiac chamber, valve, or annulus, involvement of the mitral valve or annulus is most common2; atypical locations like in the aorta,8 or left atrial appendage9 have been described. MAC-related CAT in particular seems to be associated with renal disease.…”

Section: Discussionmentioning

confidence: 99%

Cardiac calcified amorphous tumour: an unusual aetiology for recurrent cardioembolic strokes

Sharma,

Annam,

Guler

et al. 2024

BMJ Case Rep

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We report an elderly woman with vascular risk factors and recurrent cardioembolic strokes in whom the stroke aetiology was finally ascertained to be a calcified amorphous tumour of the heart after repeated negative investigations for embolic aetiology over 2 years. This report discusses the clinical and imaging characteristics of calcified amorphous tumours of the heart with emphasis of recent advances in cardiac imaging.

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Extracavitary Cardiac Calcific Amorphous Tumors Compressing Biventricular Outflow Tracts

Rajeev,

Khan,

Rodriguez

et al. 2025

JACC: Case Reports

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Calcified amorphous tumor presenting with rapid growth in the ascending aorta

Cited by 6 publications

References 10 publications

Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report

Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report

Cardiac calcified amorphous tumour: an unusual aetiology for recurrent cardioembolic strokes

Extracavitary Cardiac Calcific Amorphous Tumors Compressing Biventricular Outflow Tracts

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