Calcified gastric cancer—CT findings before and after chemotherapy Case report and discussion of the pathogenesis of this type of calcification

Clinicopathological Characteristics and Computed Tomography Features of Mucinous Gastric Carcinoma

“…35 The dystrophic calcifications of gastric carcinoma after chemotherapy (calcification in ischaemic and necrotic areas) are conglomerate. 36 Thus, miliary and punctuate calcifications within the gastric carcinoma are thought to be characteristic and diagnostic of MGC.…”

Diffuse and psammomatous calcification in intestinal type gastric carcinoma: Report of two cases with literature review

“…It has been presumed that the decrease in cellular respiration and carbon dioxide production due to insufficient blood supply secondary to ischemia and necrosis in the stomach results in relative alkalinity, and since calcium salts are hardly soluble in alkaline solutions, subsequent precipitation of calcium salts (18)(19)(20)22). It has also been suggested that mucin, a glycoprotein, has a predilection for calcification that may act as a nidus (19,20).…”

“…It has been proposed that patients with mucinous gastric cancer showing diffuse type of calcification are relatively young in age and probably have a better survival than those gastric cancer cases without calcification (18). However, it is unclear whether the calcification type -diffuse or psammomatous -is important due to the limited number of cases with psammomatous calcification.…”

“…Diffuse type calcification is generally seen within the pools of mucin in advanced diffuse type mucinous adenocarcinoma. Conversely, psammomatous calcification is associated with non-mucin-producing intestinal type carcinomas and detected not only within the carcinomatous glandular lumina but also in the stroma (17,18). Heterotropic ossification, another type of calcification, is associated with well-differentiated adenocarcinoma and may be seen in primary and metastatic localization (18).…”

“…Conversely, psammomatous calcification is associated with non-mucin-producing intestinal type carcinomas and detected not only within the carcinomatous glandular lumina but also in the stroma (17,18). Heterotropic ossification, another type of calcification, is associated with well-differentiated adenocarcinoma and may be seen in primary and metastatic localization (18). Here, we present two cases of gastric calcification -one diffuse and one psammomatous -which developed in intestinal type gastric adenocarcinomas, and we discuss the cases together with the literature.…”