Calcifying fibrous tumor: an unrecognized IgG4—related disease?

Larson, Brent K.; Balzer, Bonnie; Goldwasser, Jerome; Dhall, Deepti

doi:10.1111/apm.12302

Cited by 27 publications

(20 citation statements)

References 29 publications

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“…Furthermore, there are several articles in the English medical literature in which it is reported that CD34, CD68, IgG, and IgG4 can be occasionally focally expressed in mast cells of CFT. 99 , 106 Larson et al 66 mentioned that CFT shares certainly some morphologic features with an IgG4-related disease, as they found increased IgG4 in serum of a patient with CFT. Based on the sex predominance of these tumors, we believe that further study should be done on sex hormone receptors.…”

Section: Discussionmentioning

confidence: 99%

“…No recurrences or metastasis are observed, except for 6 cases of patients who appeared with a recurrence within their follow-up period, including 2 cases of neck CFT in an infant, 2 cases of neck CFT in 3-year-old children, 1 case of small intestine CFT in 43-year-old man, who also had a metastasis, and 1 case of upper extremities CFT in an 1-year-old child. 2 , 10 , 11 , 21 , 28 , 33 , 66 , 81 More than 88% of the patients are cured by the local surgical excision of the tumor. No deaths have been noted owing to CFT and long-term survival of patient seems to be certain.…”

Section: Discussionmentioning

confidence: 99%

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Calcifying Fibrous Tumor

2016

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Calcifying fibrous tumor (CFT) is a benign lesion characterized by its specific histological findings and is found as solitary or multiple lesions in several locations of the human body. The aim of the present systematic review is to give a detailed account of all reported cases of CFT in the literature and to analyze the available data, to completely characterize the entity from epidemiological, medical, and surgical aspects.A bibliographic research was performed from 1988 until 2015. A database with the patients’ characteristics was made, including sex, age, location of the tumor, symptoms, symptoms duration, size of the tumor, diagnostic methods, treatment, metastasis, and follow-up.A total of 104 articles were identified, reporting 157 cases of CFT. Mean age of patients was 33.58 years and the ratio between men and women was 1:1.27. The most common locations of CFT were stomach (18%), small intestine (8.7%), pleura (9.9%), mesentery (5%), and peritoneum (6.8%). Mean diameter of the tumor was estimated 4.6 cm. The correlations proceeded showed that as age increases, size decreases (P = 0.001) and that the tumor is larger in females (P = 0.027). Kruskal-Wallis test showed that the larger tumors appear in the neck and adrenal gland (P = 0.001). The percentage of asymptomatic patients was 30.57%. Computed tomography and biopsy were the most common tests for the diagnosis of CFT. Open surgical procedure was performed in the majority of cases. The median hospitalization was 6.06 days and the mean follow-up period was 29.97 months. Recurrences were mentioned in 10 of 96 patients with available data. No deaths owing to CFT were mentioned in the literature.CFT should be included in the differential diagnosis of enlarging mass revealed by clinical or imaging examination either incidentally or after specific acute or chronic symptomatology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calcifying Fibrous Tumor

2016

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“…Larson et al . [ 10 ] also suggested that CFT could be an IgG4 related disease. Although these reports support that CFT might be IgG4 related, our case was negative for IgG4 stain.…”

Section: Discussionmentioning

confidence: 99%

Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor

Kim

Min

Kim³

et al. 2015

J Pathol Transl Med

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“…It has been postulated that CFT may fall within the spectrum of IgG4related disease. 47,48 However, this is not widely accepted. Pleural CFT occurs predominantly in adult women.…”

Section: Calcifying Fibrous Tumormentioning

confidence: 99%

The Diagnosis of Pleural Tumors Other Than Mesothelioma

Attanoos¹,

Pugh

2018

Archives of Pathology &Amp; Laboratory Medicine

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- A wide variety of tumors can involve the pleura. In most cases, the approach of considering the morphologic features with appropriate immunohistochemistry, in the correct clinical context, allows for a confident diagnosis. For a number of those soft tissue tumors that are well recognized in the pleura, such as solitary fibrous tumor, desmoid-type fibromatosis, synovial sarcoma, and epithelioid hemangioendothelioma, novel markers now exist based on an understanding of the individual tumors' molecular characteristics. Primary pleural lymphomas are rare with poor prognosis. They represent localized specific diffuse large B-cell lymphomas, with either post-germinal center B-cell or plasma cell lineage, arising in the context of either immunodeficiency or immune sequestration and with viral infection.

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Calcifying fibrous tumor: an unrecognized IgG4—related disease?

Cited by 27 publications

References 29 publications

Calcifying Fibrous Tumor

Calcifying Fibrous Tumor

Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor

The Diagnosis of Pleural Tumors Other Than Mesothelioma

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