Calcifying fibrous tumor and inflammatory myofibroblastic tumor are epigenetically related: A comparative genome-wide methylation study

Tomassen, Tess; Koelsche, Christian; Leng, Wendy W.J. de; Kommoss, Felix K.F.; Voijs, Carmen M. A. de; Peeters, Ton; Noesel, Max M. van; Creytens, David; Gorp, Joost M. van; Petersen, Iver; Vokuhl, Christian; Deimling, Andreas von; Mentzel, Thomas; Flucke, Uta

doi:10.1016/j.anndiagpath.2019.05.013

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…7,9,10 Furthermore, inflammatory pseudotumour has been described in the literature by many names, including inflammatory myofibroblastic tumour (IMT), calcifying fibrous tumour, fibrous pseudotumour, inflammatory myofibrohistiocytic proliferation and inflammatory fibrosarcoma, all of which demonstrates variable histological characteristics and behaviour of these lesions. 7,11 IMT, the term that has been most used in literature in conjunction with inflammatory pseudotumours, which is reported to exhibit malignant transformation, is most commonly found in the lungs, orbit, or retroperitoneum with histology noting proliferation with prominent myofibroblastic spindle cells and histiocytes. It is noted to have varying levels of fibrosis, necrosis, and chronic inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

“…12 The distinction between the two is widely controversial, with reports suspecting that some types of inflammatory pseudotumours and IMT may represent both ends of a spectrum of one entity and is beyond the scope of this report. 2,11 Radiographically, inflammatory pseudotumours are nonspecific, featuring variable degrees of locations and attenuation that can present as distinct masses or infiltrative tissue possibly due to the fluctuating degrees of fibrosis, cellular infiltration and dynamic change during the inflammatory process. 7,[13][14][15][16] When imaged FDG, there is uptake similar to malignancy due to the infiltrating inflammatory cell composition.…”

Section: Discussionmentioning

confidence: 99%

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Rare presentation of inflammatory pseudotumour involving subcutaneous tissues with superficial fat sparing

et al. 2021

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We present a unique case of inflammatory pseudotumour involving gluteal subcutaneous tissue with the sparing of superficial fat and report its contrast-enhanced CT, F-18 fluorodeoxyglucose positron emission tomography/CT and pathological findings. Although rare, inflammatory pseudotumours have been reported with a diverse spectrum of locations; however, the involvement of the subcutaneous tissue overlying the gluteal muscles with sparing of the most superficial fat has not been reported.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rare presentation of inflammatory pseudotumour involving subcutaneous tissues with superficial fat sparing

et al. 2021

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“…Calcifying fibrous tumor must be distinguished histologically from other spindle cell tumors, including sclerosing calcified gastrointestinal stromal tumor (GIST), schwannoma, hyalinized leiomyoma, IgG4-related sclerosing disease, inflammatory myofibroblastic tumor (IMT), solitary fibrous tumor, and reactive nodular fibrous pseudotumor. 9,10 Characteristic morphologic findings of CFTs include circumscription, paucicellularity, collagenous matrix, bland spindle cells, calcifications, and a chronic lymphoplasmacytic inflammatory infiltrate. 3 However, the diagnosis often requires exclusion of more common entities which can be ruled out by a careful histological and immunohistochemical analysis and, in some cases, on genetic analysis.…”

Section: Discussionmentioning

confidence: 99%

Calcifying Fibrous Tumor of the Mesentery: A Case Report and a Review of the Literature

Derqaoui

Elouazzani

Amine

et al. 2020

Clin Med�Insights�Pathol

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Background: Calcifying fibrous tumor (CFT) is a rare entity, with a distinctive histological presentation, initially reported as childhood fibrous tumor with psammoma bodies. It is a benign hypocellular fibrous neoplasm calcifications and lymphoplasmacytic infiltrate. The CFTs may involve many sites, including gastrointestinal tract, pleura, abdominal cavity, and neck. The diagnosis might be challenging due to histological overlaps with other mesenchymal tumors. The prognosis is good. We describe herein the case of a 53-year-old woman with an incidentally diagnosed CFT of the mesentery. Case presentation: A 53-year-old woman presented to the surgery department with a 2-year history of an anterior abdominal hernia. A computed tomographic scan of the abdomen failed to demonstrate any evidence of a mesenteric nodule. The patient underwent surgical treatment. Careful exploration during the excision of herniated sac revealed a solitary nodule of the mesentery. Local excision was performed. On gross, it was a well-demarcated nodule. Microscopically, the tumor consisted of an abundant paucicellular hyalinized collagen with calcifications; associated to a sparse mononuclear inflammatory infiltrate. Conclusions: Calcifying fibrous tumor is a benign lesion. The diagnosis is based on histology, because clinical and radiological features are nonspecific. Awareness of this entity is crucial to distinguish it from other mesenchymal tumors especially in the gastrointestinal tract.

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“…Studies showing the presence of ALK rearrangements in IMT, which are not present in CFT, have suggested that CFT is a distinct neoplastic process[ 18 ]. However, genome-wide methylation analysis has shown overlapping methylation patterns of CFT and IMT, suggesting that both lesions may represent a spectrum of the same disease, irrespective of gene fusion analysis[ 19 ].…”

Section: Pathogenesismentioning

confidence: 99%

Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update

Turbiville

Zhang

2020

WJG

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Calcifying fibrous tumor (CFT) is a rare mesenchymal lesion that has been documented throughout the gastrointestinal tract. Gastrointestinal CFTs may occur at virtually any age, with a predilection for adults and for females. They occur most commonly in the stomach and the small and large intestines. CFTs are most often found incidentally, cured by local resection, and have a low risk of recurrence. Histology shows three characteristic features: Spindle cell proliferations within a densely hyalinized stroma, scattered calcifications, and lymphoplasmacytic inflammation. CFTs are immunoreactive for CD34, vimentin and factor XIIIa, helping to distinguish them from other benign mesenchymal neoplasms. The differential diagnosis of CFTs includes sclerosing gastrointestinal stromal tumor, leiomyoma, schwannoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, plexiform fibromyxoma, fibromatosis, sclerosing mesenteritis, and reactive nodular fibrous pseudotumor. The pathogenesis of CFTs remains unclear, but some have hypothesized that they may be linked to IgG4-related disease, inflammatory myofibroblastic lesions, hyaline vascular type Castleman disease, sclerosing angiomatoid nodular transformation of the spleen, or trauma.

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Calcifying fibrous tumor and inflammatory myofibroblastic tumor are epigenetically related: A comparative genome-wide methylation study

Cited by 13 publications

References 17 publications

Rare presentation of inflammatory pseudotumour involving subcutaneous tissues with superficial fat sparing

Rare presentation of inflammatory pseudotumour involving subcutaneous tissues with superficial fat sparing

Calcifying Fibrous Tumor of the Mesentery: A Case Report and a Review of the Literature

Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update

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