Calcifying Fibrous Tumor of the Gastrointestinal Tract

Abstract

Calcifying fibrous tumor is a benign mass lesion classically described as a soft tissue tumor. However, a thorough review of the literature reveals that it can occur virtually anywhere, including the tubular gastrointestinal (GI) tract. Its clinical manifestations are variable in the GI tract, and its imaging findings are nonspecific. However, it has unique histologic and immunophenotypical features that must be recognized by GI pathologists to differentiate it from an assortment of other rare mesenchymal lesions of the abdomen and GI tract. Calcifying fibrous tumor is composed of a paucicellular collagen matrix, interspersed calcified bodies, and a sparse inflammatory infiltrate. Although calcifying fibrous tumor is benign, pathologists must be aware that it may occur in the GI tract to differentiate it from other potentially more aggressive, rare mesenchymal lesions.

An Extremely Rare Case of Lower Urinary Tract Symptoms: Floating Benign Mesenchymal Mass in Abdomen

“…The pathological findings of the mass in the present case were very different from those reported in the literature, with little cellularity and much hyalinization [6, 7]. In addition, mesenchymal cells only were present on the peripheral side of the mass.…”

“…Although previous studies reported calcific fibrous masses in the gastrointestinal tract [6] and inflammatory myofibroblastic tumors [7], there have been no published reports of a free mesenchymal mass in the abdomen, notably in men. The pathological findings of the mass in the present case were very different from those reported in the literature, with little cellularity and much hyalinization [6, 7].…”

A Rare Benign Gastrointestinal Lesion Identified as a Calcifying Fibrous Tumor

“…1 Histologically they are defined by a triad of dense fibrosis, inflammation, and interspersed calcifications. 2 They are rare in the gastrointestinal tract and most gastrointestinal CFTs were reported as arising from the stomach. 1,3,4 CFT etiology is unknown, but it is thought to be the result of abnormal tissue healing, hence some authors refer to it as "calcifying fibrous pseudotumor."…”

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

“…The differential diagnosis of a well-circumscribed pancreas tumor is broad. In our case, it was important to rule out metastatic carcinoma first and then consider gastrointestinal stromal tumor, solitary fibrous tumor, and inflammatory myofibroblastic tumor [5]. The differential diagnoses of gross and histologic pathology are discussed here.…”