2020
DOI: 10.1111/iep.12339
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Calcifying fibrous tumour: An IgG4‐related disease or not?

Abstract: SummaryCalcifying fibrous tumour (CFT) has some of the histopathological features, such as abundant plasma cells and stromal fibrosis, that are exhibited by IgG4‐related diseases (IgG4‐RD). The possible role of IgG4‐positive plasma cells in calcifying fibrous tumour was investigated. The aim of this study was to determine any potential relationship between IgG4‐RD and CFT. Thirteen cases with a total of 16 CFTs were reviewed. Lesion samples were immunostained with anti‐IgG4 and anti‐IgG antibodies. The number … Show more

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Cited by 5 publications
(1 citation statement)
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“…CFT similarly shows a lymphoplasmacytic infiltrate, and the dense fibrosis seen in CFT frequently shows a vaguely but not classic storiform pattern[ 13 ]. Cases of CFT with increases in IgG4-positive plasma cells have been reported, occasionally with elevated serum IgG4[ 9 , 14 , 15 ]. However, cases of CFT in patients with other manifestations of IgG4-RD such as autoimmune pancreatitis type I are often lacking.…”
Section: Pathogenesismentioning
confidence: 99%
“…CFT similarly shows a lymphoplasmacytic infiltrate, and the dense fibrosis seen in CFT frequently shows a vaguely but not classic storiform pattern[ 13 ]. Cases of CFT with increases in IgG4-positive plasma cells have been reported, occasionally with elevated serum IgG4[ 9 , 14 , 15 ]. However, cases of CFT in patients with other manifestations of IgG4-RD such as autoimmune pancreatitis type I are often lacking.…”
Section: Pathogenesismentioning
confidence: 99%