Calcifying Pneumocystis carinii thyroiditis

O’Donovan, Maggie; Fitzpatrick, Fidelma; Mulcahy, F; Gaffney, Eoin F.

doi:10.1258/0956462971918805

Cited by 2 publications

(2 citation statements)

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“…Thyroid involvement by P. jiroveci was first described as an autopsy finding in a patient with thymic alymphoplasia presenting disseminated pneumocystosis 3 . After that, thyroiditis in the setting of disseminated extrapulmonary pneumocystosis has been described at postmortem examination in 10 patients with AIDS without description of thyroid‐related clinical findings 4–13 …”

Section: Resultsmentioning

confidence: 99%

“…Almost all patients had thyroid function evaluated and it was decreased in most of them 15–17,19,21 three patients had normal thyroid function, 9,13, 24 one had hyperthyroidism at the onset but has further developed hypothyroidism, 22 and one presented hyperthyroidism 20 . One patient developed simultaneously hypothyroidism and hypoparathyroidism 23 .…”

Section: Resultsmentioning

confidence: 99%

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Pneumocystis jiroveci thyroiditis: report of 15 cases in the literature

Zavascki

Maia

Goldani

2007

Mycoses

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The authors review the epidemiology, clinical manifestations, diagnosis and treatment of Pneumocystis jiroveci thyroiditis of 15 cases reported in the medical literature. Patients with acquired immunodeficiency disease syndrome were particularly at risk. P. jiroveci thyroiditis was diagnosed at autopsy as a part of disseminated infection in a substantial number of patients without clinical manifestations and laboratory evidence of thyroid dysfunction. Local signs and symptoms of infection were indistinguishable from other infectious thyroiditis and included neck enlargement with or without cervical pain, sometimes associated with dysphagia and dysphonia, and clinical and laboratory features of hypothyroidism. Antemortem diagnosis of fungal thyroiditis was made by direct microscopy and culture of a fine-needle aspirate in most cases. As most patients with P. jiroveci thyroiditis had disseminated Pneumocystis infection with a delay in diagnosis and treatment, the overall mortality was high. Pneumocystis jiroveci thyroiditis is rare but should be suspected in HIV-infected patients with CD4 count lower than 200 cells micro(-1) on prophylatic inhalatory pentamidine who present with neck enlargement with or without pain, and clinical and laboratory evidence of hypothyroidism.

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Section: Resultsmentioning

confidence: 99%