Calcifying Pseudoneoplasm of the Cervicomedullary Junction: Case Report and a Literature Review

Alshareef, Mohammed; Vargas, Jan; Welsh, Cynthia T.; Kalhorn, Stephen P.

doi:10.1016/j.wneu.2015.08.055

Cited by 21 publications

(38 citation statements)

References 32 publications

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“…The most characteristic radiological feature of CAPNON is dense calcification . For intracranial lesions, differential diagnoses include astrocytoma, oligodendroglioma, choroid plexus papilloma, meningioma, craniopharyngioma, ependymoma, cavernous angioma, chondrosarcoma, chondroblastoma, chondroma, calcified metastatic brain tumor and tuberculoma . In previous reports, CT images of CAPNON typically showed solid calcifications, and MRI often revealed a well‐defined lesion that was uniformly hypointense on both T1‐ and T2‐weighted images without perilesional edema .…”

Section: Discussionmentioning

confidence: 98%

“…To our knowledge, there are few reports of CAPNON in association with a neoplasm. CAPNON are typically slow‐growing, benign, non‐infiltrative lesions that can be treated with gross total resection and generally have excellent prognosis . The most characteristic radiological feature of CAPNON is dense calcification .…”

Section: Discussionmentioning

confidence: 99%

“…Rhodes and Davis reported the first series of CAPNON in 1978 . Since then, there have been 68 reported cases . CAPNON are typically indolent and show excellent prognosis with gross total resection …”

Section: Introductionmentioning

confidence: 99%

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Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low‐grade glioma: A case report and review of the literature

et al. 2017

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Calcifying pseudoneoplasms of the neuraxis (CAPNON) are presumed to be a non-neoplastic reactive pathology, based on the frequent finding of granulomatous inflammation. To our knowledge, there are few reports of CAPNON in association with a neoplasm. Here, we report the case of a 62-year-old man presenting with headache, which was caused by CAPNON in the left cingulate gyrus. CT scan revealed a calcified mass exhibiting gradual growth and increasing peritumoral edema. MRI showed an intra-axial hypointense mass on T1- and T2-weighted images. Development of a peri-lesional hyperintense lesion on T2-weighted images suggested local edema or tumoral invasion. Gadolinium-enhanced T1-weighted images revealed mild peripheral enhancement of the calcified nodule. L-methyl- C methionine-positron emission tomography revealed the uptake of tracer in the calcified nodule. The calcified mass and its enveloping brain tissue were removed using a parietal craniotomy. The calcified tissue was surrounded by spindle-shaped cells positive for GFAP and nestin. The MIB-1 labeling index of spindle cells was around 10% (i.e. a hot spot). Fourteen months after surgery, gadolinium-enhanced MRI evidenced growth of a tiny residual lesion. Therefore, this report illustrates a potential case of CAPNON arising from low-grade glial neoplasm.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low‐grade glioma: A case report and review of the literature

et al. 2017

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“…On imaging, they can easily be confused with malignant lesions such as chondrosarcoma or chondroblastoma or even more benign pathologies such as meningioma (4). CT images typically show solid areas of calcification and MR imaging often shows a well-defined lesion that is hypointense in T1 and T2-weighted images without any brain edema.…”

Section: Discussionmentioning

confidence: 99%

“…Although typically benign, symptoms of CAPNONs typically present secondary to compression and surrounding mass effect (4). Various symptoms and signs will therefore appear according to their location.…”

Section: Introductionmentioning

confidence: 99%

A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident

Zerehpoosh¹,

Samadian²,

Azhari³

et al. 2016

TJPATH

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Calcifying pseudoneoplasms of the neuraxis are rare, poorly understood lesions that can occur anywhere in the central nervous system without any age or sex predilection. Their pathogenesis is still controversial. Patients can present with various symptoms due to lesion location and only few cases have been discovered incidentally. We present a 25-year-old male referred to our hospital after a car accident. Computed tomography scan and magnetic resonance imaging was done because of the patient's head trauma and a calcified intracranial lesion was found and excised surgically. Pathologic evaluation of the specimen was consistent with the diagnosis of calcifying pseudoneoplasm of the neuraxis.

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Giant calcified pseudoplasm of the nerve axis of the temporal lobe: a case report and review of the literature

Xiang

Liang

et al. 2021

Acta Neurol Belg

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Calcifying Pseudoneoplasm of the Cervicomedullary Junction: Case Report and a Literature Review

Cited by 21 publications

References 32 publications

Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low‐grade glioma: A case report and review of the literature

Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low‐grade glioma: A case report and review of the literature

A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident

Giant calcified pseudoplasm of the nerve axis of the temporal lobe: a case report and review of the literature

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