2024
DOI: 10.1128/msphere.00554-23
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Calcineurin-dependent contributions to fitness in the opportunistic pathogen Candida glabrata

Matthew W. Pavesic,
Andrew N. Gale,
Timothy J. Nickels
et al.

Abstract: The protein phosphatase calcineurin is vital for the virulence of the opportunistic fungal pathogen Candida glabrata . The host-induced stresses that activate calcineurin signaling are unknown, as are the targets of calcineurin relevant to virulence. To potentially shed light on these processes, millions of transposon insertion mutants throughout the genome of C. glabrata were profiled en masse for fitness defects in the presence of FK506,… Show more

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