2017
DOI: 10.1681/asn.2017080830
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Calcineurin Inhibitors in the Treatment of Lupus Nephritis: A Hare Versus Turtle Story?

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Cited by 9 publications
(4 citation statements)
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“…In a trial evaluating a combination of calcineurin inhibitor, mycophenolate mofetil and GCs vs. intravenous cyclophosphamide, all patients received three 0.5 g/day methylprednisolone pulses followed by 0.6 mg/kg oral prednisone slowly tapered to 10 mg/day by week 16. Response rates of 84 and 63% at 6-months, were documented in the multi-targeted therapy and cyclophosphamide groups, respectively, and of 78% in both groups by 2 years of therapy ( 81 83 ).…”
Section: The Use Of Intravenous Methylprednisolone Pulses To Limit Glmentioning
confidence: 95%
“…In a trial evaluating a combination of calcineurin inhibitor, mycophenolate mofetil and GCs vs. intravenous cyclophosphamide, all patients received three 0.5 g/day methylprednisolone pulses followed by 0.6 mg/kg oral prednisone slowly tapered to 10 mg/day by week 16. Response rates of 84 and 63% at 6-months, were documented in the multi-targeted therapy and cyclophosphamide groups, respectively, and of 78% in both groups by 2 years of therapy ( 81 83 ).…”
Section: The Use Of Intravenous Methylprednisolone Pulses To Limit Glmentioning
confidence: 95%
“…It is well known that SLE has different clinical expressions and responses to treatment depending on ethnic groups. These results should be taken with caution when applied to other groups [17][18][19]. The "Rituxilup" scheme, consisting of rituximab and MP (500 mg on days 1 and 15), followed by maintenance treatment with mycophenolate mofetil without oral steroids, resulted in 72% of LN patients achieving complete remission.…”
Section: Looking For Allies (Keep Your Friends Close)mentioning
confidence: 94%
“…No patients in the 1500 mg group suffered infections, vs. 9.1% in the other groups. Other studies demonstrated the efficacy of lower doses of iv MP pulse as seen above (ELNT, MYLUPUS, Rituxilup, "Lupus Cruces", AURA, AURORA) [15][16][17][18][19][20][21][22][23][24][25]. Pulses of iv Prednisolone 125 mg, as a unique dose, have been successfully used in moderate flares to induce rapid remission and avoid higher oral doses for long periods [32].…”
Section: Looking For Allies (Keep Your Friends Close)mentioning
confidence: 95%
“…8 Combining CNIs with standard induction therapy for LN may increase the likelihood of complete renal remission. 9 Voclosporin, structurally similar to cyclosporine, is a novel CNI for treating LN. 10 Tacrolimus, a potent T-cell proliferation inhibitor, inhibits calcineurin by binding to tacrolimus-binding proteins on T cells.…”
Section: Introductionmentioning
confidence: 99%