Calcinosis cutis following liver transplantation: a complication of intravenous calcium administration

Jucglà, Anna; Sais, Gemma; Curcó, N.; Marcoval, Joaquim; Moreno, Abelardo; Peyrı́, Jordi

doi:10.1111/j.1365-2133.1995.tb05026.x

Cited by 23 publications

(14 citation statements)

References 11 publications

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“…150 Calcium gluconate is also the preferred salt for peripheral venous administration since calcium chloride infusion may cause tissue necrosis if extravasation occurs. 153,154 Calcium should not be infused in the same i.v. catheter as solutions containing phosphate because of the risk of calciumphosphate precipitation.…”

Section: Calciummentioning

confidence: 99%

Treatment of electrolyte disorders in adult patients in the intensive care unit

Kraft

Btaiche²,

Sacks³

et al. 2005

American Journal of Health-System Pharmacy

241

202

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Purpose. The treatment of electrolyte disorders in adult patients in the intensive care unit (ICU), including guidelines for correcting specific electrolyte disorders, is reviewed. Summary. Electrolytes are involved in many metabolic and homeostatic functions. Electrolyte disorders are common in adult patients in the ICU and have been associated with increased morbidity and mortality, as has the improper treatment of electrolyte disorders. A limited number of prospective, randomized, controlled studies have been conducted evaluating the optimal treatment of electrolyte disorders. Recommendations for treatment of electrolyte disorders in adult patients in the ICU are provided based on these studies, as well as case reports, expert opinion, and clinical experience. The etiologies of and treatments for hyponatremia hypotonic and hypernatremia (hypovolemic, isovolemic, and hypervolemic), hypokalemia and hyperkalemia, hypophosphatemia and hyperphosphatemia, hypocalcemia and hypercalcemia, and hypomagnesemia and hypermagnesemia are discussed, and equations for determining the proper dosages for adult patients in the ICU are provided. Treatment is often empirical, based on published literature, expert recommendations, and the patient's response to the initial treatment. Actual electrolyte correction requires individual adjustment based on the patient's clinical condition and response to therapy. Clinicians should be knowledgeable about electrolyte homeostasis and the underlying pathophysiology of electrolyte disorders in order to provide the optimal therapy to patients. Conclusion. Treatment of electrolyte disorders is often empirical, based on published literature, expert opinion and recommendations, and patient's response to the initial treatment. Clinicians should be knowledgeable about electrolyte homeostasis and the underlying pathophysiology of electrolyte disorders to provide optimal therapy for patients.

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Section: Calciummentioning

confidence: 99%

Treatment of electrolyte disorders in adult patients in the intensive care unit

Kraft

Btaiche²,

Sacks³

et al. 2005

American Journal of Health-System Pharmacy

241

202

View full text Add to dashboard Cite

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“…Therefore, calcification can be metastatic, or local trauma because of subcutaneous injections can be precipitate calcification (dystrophic). [17][18][19] In our report, we had 2 cases with calcinosis cutis, and they both occurred on the hands of these patients. In both cases, serum calcium levels were within normal limits.…”

Section: Discussionmentioning

confidence: 99%

“…Four different types of calcinosis cutis can be identified: dystrophic, metastatic, idiopathic, and iatrogenic. 17,18 Dystrophic calcinosis is the most common type and occurs in previously damaged tissue. Metastatic calcinosis occurs in normal tissues as a result of a disturbance in systemic calcium homeostasis, such as renal failure.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

Exp Clin Transplant

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Objectives: This study sought to analyze the incidence and risk factors of skin complications in liver transplant recipients. Materials and Methods: Patients with skin biopsies were selected from 408 liver transplant recipients from January 1990 to December 2012 at Baskent University in Ankara, Turkey. Demographic and clinical findings including age, sex, primary liver disease, immunosuppressive therapy, and the time between transplant and cutaneous lesions were examined. Results: There were 38 patients who had skin biopsy after liver transplantation. The mean age at transplantation was 30.5 years. The primary liver disease was hepatocellular carcinoma seconder to viral hepatitis in 15 patients, Wilson disease in 7 patients, criptogenic cirrhosis in 3, familial hypercholesterolemia in 3 patients, and 1 each patients of Byler disease, Caroli disease, tyrosinemia, Budd-Chiari sendrom, congenital hepatic fibrosis, alcholic cirrhosis, and biliar atresia. The primary disease in 3 patients were unknown. The histologic diagnosis included precancerous and cancerous lesions (n=4), infectious diseases (n=4); xanthomatous lesions (n=4); vasculopathic lesions (n=4); melanocytic lesions (n=4); benign adnexial tumors (n=2); skin atrophy (n=2); calcinosis cutis (n=2), keratinous cyst (n=2), neutrophilic dermatosis (n=2), perivascular dermatitis (n=2) and miscellaneous lesions (n=6). Conclusions:We presented the cutaneous manifestations in liver transplant recipients. The most common skin lesion in these patients were precancerous and cancerous lesions, infectious, xanthomatous, and melanocytic lesions. The findings emphasize the importance of dermatologic screening in these patients that can provide early diagnosis and a better quality of life.

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“…Numerous cases of calcinosis cutis have been reported after solid organ transplantation [6][7][8] . After liver transplantation, soft tissue calcifi cations have been described in 47-84% of cases, most frequently in the lungs, blood vessels, kidneys, pancreas, liver graft, adrenal glands, colon and gastric mucosa.…”

mentioning

confidence: 99%

“…In contrast, cutaneous calcifi cations were rarely observed [2][3][4][5][6][7] and more often caused by extravasation of intravenous calcium solution [6] . These dystrophic calcifi cations occurred usually at the site of injection or at different localizations along the extremity receiving the intravenous catheter [6,9] .…”

mentioning

confidence: 99%