Calcinosis estriado-pálido-dentada como causa de extrapiramidalismo en una paciente con hipoparatiroidismo primario

Nicolau, Joana; Ibáñez, Ana María Espino; Irigoín, Rosameri Rivera; Artigas, Carla Francés; Comas, Lluís Masmiquel

doi:10.1016/j.endonu.2011.03.008

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Especially in HPT, the early treatment can prevent calcification and neurophysiological disorders. [111224] Our patient showed response with Risperidone 1 mg, Lorazepam 2 mg and Oxcarbazapine 300 mg in around 20 days. Studies show that psychosis in setting of Fahr's disease is known to respond variably to treatment and is sometimes unresponsive.…”

Section: Discussionmentioning

confidence: 78%

“…Fahr's syndrome is mostly associated with a disorder of calcium and phosphate metabolism, especially due to hypoparathyroidism (HPT),[11121314] but can also be due to other different etiologies, including infectious, metabolic, and genetic diseases. [15] Our patient did not have any abnormality in calcium and phosphate levels, but parathyroid level was low which may be the reason for BGC in our patient.…”

Section: Discussionmentioning

confidence: 99%

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A case of psychosis due to Fahr′s syndrome and response to behavioral disturbances with risperidone and oxcarbazepine

Faye

Gawande

Tadke

et al. 2014

Indian J Psychiatry

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Calcification of basal ganglia or Fahr's syndrome is a rare disease characterized by bilateral and symmetrical intracranial deposition of calcium mainly in cerebral basal ganglia. Motor and neuropsychiatric symptoms are prominent features. We report a case presented with a few motor symptoms, features of delirium and prominent psychiatric symptoms (disorganized behavior) predominantly evident after the improvement in delirium. Radiological findings were suggestive of bilateral basal ganglia calcification. Parathyroid hormone levels were low with no significant findings in other investigations and negative family history. Patient showed significant improvement in behavioral disturbances with risperidone, low dose of lorazepam, oxcarbazepine, and memantine.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

A case of psychosis due to Fahr′s syndrome and response to behavioral disturbances with risperidone and oxcarbazepine

Faye

Gawande

Tadke

et al. 2014

Indian J Psychiatry

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“…A study by Ramis et al determined the disturbance in the calcium and phosphate metabolism in this rare neurological disorder, which leads to hypocalcemia and hypoparathyroidism [ 7 , 8 ]. Other possible etiologies of Fahr's syndrome include infections, metabolic, and genetic diseases [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Manifestations in Fahr's Syndrome: A Case Report

Kumar¹,

Singh²,

Shah³

2020

Cureus

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Fahr's syndrome is a rare neurological entity, primarily impacting basal ganglia with bilateral intracranial calcium deposition. It mainly manifests motor and psychiatric symptoms in affected individuals. After the patient and her family members' consent and proper ethical clearance from the institutional ethical committee, we here report a case presented with a few motor symptoms, features of delirium, and prominent psychiatric symptoms such as disorganized behavior, auditory hallucinations, and delusions. The imaging study found bilateral basal ganglia calcification and edema in the parietal region, primarily on the right side. Laboratory studies revealed mildly low parathyroid hormone and calcium levels, but no significant findings in other investigational tests. Her past medical and psychiatric history were negative, except for her well-adjusted pre-morbid personality. Our aim through this case is to highlight the psychiatric manifestation of a rare neurological syndrome. It also showcases the importance of ruling out medical causes when a patient presents primarily with behavioral symptoms.

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“…BGC is usually associated with disturbed calcium or phosphate metabolism due to hypoparathyroidism or Fanconi syndrome [11–14]. MIDs with BGC, however, do not always show an association with parathyroid dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Basal Ganglia Calcification with Tetanic Seizure Suggest Mitochondrial Disorder

2017

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Patient: Female, 65Final Diagnosis: Mitochondrial disorderSymptoms: Headache • tetanic seizureMedication: DiazepamClinical Procedure: AdmissionSpecialty: NeurologyObjective:Challenging differential diagnosisBackground:Basal ganglia calcification (BGC) is a rare sporadic or hereditary central nervous system (CNS) abnormality, characterized by symmetric or asymmetric calcification of the basal ganglia.Case Report:We report the case of a 65-year-old Gypsy female who was admitted for a tetanic seizure, and who had a history of polyneuropathy, restless-leg syndrome, retinopathy, diabetes, hyperlipidemia, osteoporosis with consecutive hyperkyphosis, cervicalgia, lumbalgia, struma nodosa requiring thyroidectomy and consecutive hypothyroidism, adipositas, resection of a vocal chord polyp, arterial hypertension, coronary heart disease, atheromatosis of the aorta, peripheral artery disease, chronic obstructive pulmonary disease, steatosis hepatis, mild renal insufficiency, long-term hypocalcemia, hyperphosphatemia, impingement syndrome, spondylarthrosis of the lumbar spine, and hysterectomy. History and clinical presentation suggested a mitochondrial defect which also manifested as hypoparathyroidism or Fanconi syndrome resulting in BGC. After substitution of calcium, no further tetanic seizures occurred.Conclusions:Patients with BGC should be investigated for a mitochondrial disorder. A mitochondrial disorder may also manifest as tetanic seizure.

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Calcinosis estriado-pálido-dentada como causa de extrapiramidalismo en una paciente con hipoparatiroidismo primario

Cited by 6 publications

References 6 publications

A case of psychosis due to Fahr′s syndrome and response to behavioral disturbances with risperidone and oxcarbazepine

A case of psychosis due to Fahr′s syndrome and response to behavioral disturbances with risperidone and oxcarbazepine

Psychiatric Manifestations in Fahr's Syndrome: A Case Report

Basal Ganglia Calcification with Tetanic Seizure Suggest Mitochondrial Disorder

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