Calcinosis Universalis in Adult-onset Dermatomyositis

Novella-Navarro, Marta; Gómez, María del Mar; Ossorio, Juan Salvatierra

doi:10.1016/j.reumae.2016.05.013

Cited by 1 publication

(1 citation statement)

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“…3 In one report, CU preceded the diagnosis of breast cancer. 13 There are two types of breast calcification; type I is calcium oxalate crystals, while type II is composed of a bone-specific mineral called HA and this is the same as the component found in CU. Of the two types, type II is found exclusively in malignant breast disease, and these crystals are known to accelerate the pathologic process in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Calcinosis universalis and breast cancer: A distinctive association

Hashimah

Kan

Raymond

2022

Journal of the Royal College of Physicians of Edinburgh

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Calcinosis universalis (CU) is characterised by diffuse deposition of insoluble calcium salt in the skin, subcutaneous tissue or organs. Calcium deposits in the breast may be associated with an increased risk for developing breast cancer. We present a case of a 65-year-old woman diagnosed with CU secondary to undifferentiated connective tissue disease. She developed progressive calcification of her skin, which did not improve with oral medications aimed at reducing the calcification. Investigations to look for possible causes of calcification were all unremarkable. During follow-up, calcification was also found in both her breasts. Initial mammography was reported as fibroadenoma. However, 3 years later, she returned with metastatic breast cancer which presented with a massive pleural effusion of the right lung. Calcinosis universalis should now be considered as a risk factor for breast cancer.

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Section: Discussionmentioning

confidence: 99%