Calciphylaxie non urémique iatrogène : une nouvelle observation

Hamich, Soumaya; Rakotoson, Julien; Mazereeuw, M.; Tristani, Hugo; Lavelle, Olivier; Sánchez, M. José Gutiérrez; Lagrange, Brigitte

doi:10.1016/j.nephro.2020.09.002

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…28 Other case studies are confirming the positive effects of Rh in this extremely severe clinical condition. [29][30][31] A randomized trial is scheduled to study Rh as an adjuvant therapy for calciphylaxis is under way (RHEO-CAL). 39…”

Section: Technical Parameters Of Rheopheresismentioning

confidence: 99%

Rheopheresis: A narrative review

Kosmadakis

2022

Int J Artif Organs

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Introduction: Rheopheresis is an extracorporal selective double-filtration procedure with an initial separation of plasma from the whole blood and a further filtration of the plasma through a second filter in order to eliminate a certain number of high molecular weight proteins such LDL, Lp(a), fibrinogen, α2-macroglobulin, Factor von Willebrand, and IgM Immunoglobulin. Methods: In this narrative review we discuss the available data on the effects of Rheopheresis in various clinical conditions. Results: Rheopheresis is considerd to exert a rapid effect on clinical conditions associated with seriously affected microcirculation and rheologic parameters such as, the dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHS), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis and diabetic foot. Conclusions: Rheopheresis is a promising technique for conditions associated with affected microcirculatory rheologic parameters

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Section: Technical Parameters Of Rheopheresismentioning

confidence: 99%

Rheopheresis: A narrative review

Kosmadakis

2022

Int J Artif Organs

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Multiple drugs

2021

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Warfarin-induced calciphylaxis-related skin ulceration in patients with end-stage renal disease: case report and literature review

Vallini,

Andreini,

Sibilia

et al. 2024

J Wound Care

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Calciphylaxis is a rare but highly disabling disease, occurring both in chronic kidney disease (CKD) with renal replacement therapy (RRT) and in normal renal function. Given the frequent coexistence of atrial fibrillation (AF) and CKD, anticoagulation is often required. Warfarin, as a promoter of vascular calcification, is frequently reported as a triggering factor of calciphylaxis. Here, we present the case of a 71-year old male patient with a history of AF and a previous ischaemic stroke, on RRT for three years and warfarin therapy. The patient presented with two painful necrotic skin ulcers over the right leg and a skin biopsy confirmed calciphylaxis. After discontinuation of warfarin, the lesions completely healed with sodium thiosulfate intravenous infusion and local wound treatment. A literature search was performed up to 1 September 2022 through PubMed. The following terms were searched in different combinations: ‘calciphylaxis’; ‘VKA’ [vitamin K antagonist]; ‘warfarin’; ‘haemodialysis’; ‘end-stage renal disease’; and ‘ulcer’. In our opinion, in patients requiring anticoagulant therapy, the introduction or continuation of vitamin K antagonists (VKAs) should be carefully balanced when calciphylaxis develops, and other options, such as enoxaparin or apixaban, should be considered. Clinical decisions for patients requiring haemodialysis and requiring anticoagulant therapy should take into account the possible risk of warfarin-induced calciphylaxis. Further studies are needed to clarify the safety, tolerability profile and outcomes of each currently available treatment in this patient population.

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Calciphylaxie non urémique iatrogène : une nouvelle observation

Cited by 3 publications

References 22 publications

Rheopheresis: A narrative review

Rheopheresis: A narrative review

Multiple drugs

Warfarin-induced calciphylaxis-related skin ulceration in patients with end-stage renal disease: case report and literature review

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