Calciphylaxis in a Young Adult with Acute Kidney Injury and Recently Diagnosed End-stage Liver Disease

Calciphylaxis and Kidney Disease: A Review

“…1 While uremic calciphylaxis has predominantly been linked to ESKD, more case reports suggest that this rare depositional vasculopathy may appear in the context of early kidney injury including acute kidney injury (AKI). [11][12][13][14][15][16] A case report described the appearance of calciphylaxis in the bilateral thighs of a woman three months after developing painless hematuria and nephrotic-range proteinuria in the setting of anti-GBM disease. 17 Furthermore, a population of non-uremic (nontraditional) patients may develop calciphylaxis despite normal kidney and parathyroid function.…”

Calciphylaxis in a Patient With Lupus Nephritis and Acute Kidney Injury: A Rare Case Report and Literature Review

“…2,11 Limited cases have been reported on calciphylaxis in patients with AKI due to decompensated alcoholic cirrhosis or severe clinical conditions such as necrotizing fasciitis who undergo dialysis, ranging from 29 to 65 years. [13][14][15][16][17] However, there are no documented reports of patients with lupus neph ritis with significant kidney damage who had calciphylaxis.…”

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“…Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare life-threatening vasculopathy, characterized by deposition of calcium in the arteriolar microvasculature of the deep dermis and subcutaneous adipose tissue, resulting in intensely painful, ischemic skin lesions [1]. Although uremic calciphylaxis typically affects patients with end-stage chronic kidney disease, it can also occur in patients with earlier stages of chronic kidney disease (CKD) [2], acute kidney injury [3][4][5], prior receipt of a kidney transplant [6] and even with normal kidney function. The largest nationwide study to date estimates an incidence rate of 3.49 per 1,000 patient-years among patients receiving maintenance hemodialysis [7].…”