2023
DOI: 10.1007/s13555-023-01003-0
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Calcipotriol and Betamethasone Dipropionate Cream Based on PAD Technology for the Treatment of Plaque Psoriasis: A Narrative Review

Tiago Torres,
Jordi Galván,
Nigel Crutchley
et al.

Abstract: Topical treatment plays a crucial role in psoriasis management, with non-adherence being a major barrier to treatment success. The fixed-dose combination of calcipotriol (CAL) and betamethasone dipropionate (BDP) represents the first-line choice in topical psoriasis treatment. A CAL/BDP cream based on polyaphron dispersion (PAD) Technology has emerged as a novel formulation for a more convenient topical treatment of psoriasis. This article aims to summarize the most relevant published evidence about CAL/BDP PA… Show more

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“…Novel vitamin D metabolites can stimulate Nrf2 [205], and therefore, they could potentially be used in the treatment of vitiligo or atopic dermatitis [269]. Vitamin D analogs, calcipotriol (available as an ointment and cream) and tacalcitrol, are used for the topical treatment of plaque psoriasis [270]. These lesions are characterized by hyper-proliferation and impaired differentiation of keratinocytes in a response to inflammation.…”
Section: Current and Future Applications Of Vitamin D Hydroxyderivati...mentioning
confidence: 99%
“…Novel vitamin D metabolites can stimulate Nrf2 [205], and therefore, they could potentially be used in the treatment of vitiligo or atopic dermatitis [269]. Vitamin D analogs, calcipotriol (available as an ointment and cream) and tacalcitrol, are used for the topical treatment of plaque psoriasis [270]. These lesions are characterized by hyper-proliferation and impaired differentiation of keratinocytes in a response to inflammation.…”
Section: Current and Future Applications Of Vitamin D Hydroxyderivati...mentioning
confidence: 99%