Calcitonin gene-related peptide: Detailed immunohistochemical distribution in the central nervous system

Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

“…In mammals, the major location of CGRP and its specific receptor is in the central and peripheral nervous system. (41)(42)(43) The wide distribution of CGRP in the brain suggests a function as neuromediator or neuromodulator and involvement in various brain functions. (44)(45)(46) CGRP appears to play a similar role as neuromediator or neuromodulator in sauropsids and amphibians.…”

Muscle Contracture and Twitch Depression Induced by Arsenite in the Mouse Phrenic Nerve-Diaphragm

“…On the other hand, it is generally accepted that hypothalamic nuclei such as the paraventricular nucleus (PVN) is the higher center for central regulation of sympathetic functions. Furthermore, CGRP is abun dantly contained in the hypothalamus (12,13). However, there is still a paucity of information about the possible roles of hypothalamic a-CGRP in the regulation of sym patho-adrenomedullarly outflow.…”

Long-Term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves in Spontaneously Hypertensive Rats

“…In previous reports, non-adrenergic non-cholinergic vasodilator nerves have been shown to densely inner-vate the rat mesenteric resistance artery, and calcitonin generelated peptide (CGRP), a potent vasodilator neuropeptide, has been shown to act as a vasodilator neurotransmitter of NANC nerves (1−4). CGRP is distributed throughout the central and peripheral nervous systems and is located in areas involved in cardiovascular function (5). The dorsal root ganglia (DRG) is a prominent site of CGRP synthesis and contains the cell bodies of primary afferent neurons that extend CGRP-containing nerves (CGRPergic nerves) to peripheral sites such as the blood vessels and the central spinal cord (6).…”