Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro

Duan, Jia‐Xi; Zhou, Yong; Zhou, Aiyuan; Guan, Xin‐Xin; Liu, Tian; Yang, Huihui; Xie, Haipeng

doi:10.1016/j.molimm.2017.08.020

Cited by 78 publications

(53 citation statements)

References 43 publications

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“…Nevertheless, it is known that the expression of this substance within the autonomic peripheral nervous system increases during inflammatory processes. Moreover, the latest research has shown that CGRP suppresses the expression of inflammatory cytokines in the macrophages and increases the expression of anti-inflammatory factors (Duan et al 2017 ). So changes in the expression of neuronal factors may result from inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

et al. 2019

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Bisphenol A, a substance commonly used in plastic manufacturing, is relatively well known as an endocrine disruptor, which may bind to estrogen receptors and has multidirectional negative effects on both human and animal organisms. Previous studies have reported that BPA may act on the reproductive organs, but knowledge concerning BPA-induced changes within the nerves located in the uterine wall is extremely scant. The aim of this study was to investigate the impact of various doses of BPA on the parasympathetic nerves located in the corpus and horns of the uterus using a single and double immunofluorescence method. The obtained results have shown that BPA may change not only the expression of vesicular acetylcholine transporter (VAChT—a marker of parasympathetic nervous structures) in the uterine intramural nerve fibers, but also the degree of colocalization of this substance with other neuronal factors, including substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), and calcitonin gene–related peptide (CGRP). Moreover, BPA caused changes in the density of the overall populations of fibers immunoreactive to the particular neuropeptides mentioned above. The characteristics of the changes clearly depended on the part of the uterus, the neuronal factors studied, and the dosage of BPA. The mechanisms of the observed fluctuations are probably connected with the neurotoxic and/or pro-inflammatory activity of BPA. Moreover, the results have shown that even low doses of BPA are not neutral to living organisms. Changes in the neurochemical characterization of nerves supplying the uterine wall may be the first subclinical sign of intoxication with this substance.

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Section: Discussionmentioning

confidence: 99%

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

et al. 2019

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“…Therefore, modulation of macrophage activation and polarization is an effective therapeutic approach in the treatment of ARDS/ALI. A body of evidences showed that macrophages can be modulated by many reagents (4)(5)(6)(7). Our previous research revealed that antioxidant resveratrol can attenuate ALI through polarization of alternatively activated macrophage or M2 cells (8).…”

Section: Introductionmentioning

confidence: 99%

Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages

et al. 2020

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“…3). [19][20][21][22][23][24] Unknown Knowns.-In this context, unknown knowns refers to aspects of preventive treatment that are known to be effective but are not widely used. The consequence of this lack of utilization is that the perceived need for new treatments is greater.…”

Section: Discussionmentioning

confidence: 99%

The Future of Migraine Prevention

Cowan

2018

Headache

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Barring unforeseen circumstances, we anticipate the arrival of the first mechanism‐specific class of molecules for migraine prevention in 2018. Despite many ground‐breaking advances in the field over the last several years, these agents, broadly identified as calcitonin gene‐related peptide‐based pharmaceuticals, have captured the imagination and attention of the lay press and much of the headache community. This paper will address the factors, both class‐specific and systems‐based, that are likely to affect the launch, access, compliance, and adherence related to this new class, as well as attempt to place these novel medications in context of the current state and anticipated changes in headache medicine.

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Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro

Cited by 78 publications

References 43 publications

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages

The Future of Migraine Prevention

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