Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice

Schavinski, Aline Zanatta; Machado, Juliano; Morgan, Henrique Jorge Novaes; Lautherbach, Natália; Paula-Gomes, Sílvia; Kettelhut, Ísis C.; Navegantes, Luiz Carlos Carvalho

doi:10.1016/j.peptides.2021.170677

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Furthermore, coinciding with its interactions in vascular smooth muscle and endothelial cells, CGRP has similarly been demonstrated to bind to its canonical receptor complex and activate Gα s -signaling in cardiomyocytes (Huang et al, 1999;Sueur et al, 2005;Schavinski et al, 2021). It is well established that an increase in cAMP concentration followed by PKA activation leads to phosphorylation of key Ca 2+handling proteins including phospholamban, ryanodine receptor, voltage-gated L-type Ca 2+ channels, troponin I, and myosin binding protein C; all which play an essential role in cardiac excitability and contraction (Zaccolo, 2009).…”

Section: Calcitonin Gene-related Peptide In the Myocardium -Vascular-...mentioning

confidence: 97%

The Vascular-Dependent and -Independent Actions of Calcitonin Gene-Related Peptide in Cardiovascular Disease

Argunhan

Brain

2022

Front. Physiol.

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The treatment of hypertension and heart failure remains a major challenge to healthcare providers. Despite therapeutic advances, heart failure affects more than 26 million people worldwide and is increasing in prevalence due to an ageing population. Similarly, despite an improvement in blood pressure management, largely due to pharmacological interventions, hypertension remains a silent killer. This is in part due to its ability to contribute to heart failure. Development of novel therapies will likely be at the forefront of future cardiovascular studies to address these unmet needs. Calcitonin gene-related peptide (CGRP) is a 37 amino acid potent vasodilator with positive-ionotropic and -chronotropic effects. It has been reported to have beneficial effects in hypertensive and heart failure patients. Interestingly, changes in plasma CGRP concentration in patients after myocardial infarction, heart failure, and in some forms of hypertension, also support a role for CGRP on hemodynamic functions. Rodent studies have played an important role thus far in delineating mechanisms involved in CGRP-induced cardioprotection. However, due to the short plasma half-life of CGRP, these well documented beneficial effects have often proven to be acute and transient. Recent development of longer lasting CGRP agonists may therefore offer a practical solution to investigating CGRP further in cardiovascular disease in vivo. Furthermore, pre-clinical murine studies have hinted at the prospect of cardioprotective mechanisms of CGRP which is independent of its hypotensive effect. Here, we discuss past and present evidence of vascular-dependent and -independent processes by which CGRP could protect the vasculature and myocardium against cardiovascular dysfunction.

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Section: Calcitonin Gene-related Peptide In the Myocardium -Vascular-...mentioning

confidence: 97%

The Vascular-Dependent and -Independent Actions of Calcitonin Gene-Related Peptide in Cardiovascular Disease

Argunhan

Brain

2022

Front. Physiol.

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“…CGRP, a 37-residue peptide produced in specific neurons by alternative splicing of the calcitonin gene, is an important neuropeptide involved in bone growth and metabolism, which is widely distributed throughout the central and peripheral nervous systems [ 7 ]. After being synthesized by sensory nerves, CGRP could be released from the terminal of these nerves in bone tissue following neuronal depolarization and exerts its biological functions during bone regeneration [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Neural Peptide α-CGRP Coregulated Angiogenesis and Osteogenesis via Promoting the Cross-Talk between Mesenchymal Stem Cells and Endothelial Cells

Shi

Wang

Deng

et al. 2022

BioMed Research International

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Background. The coupled vascularization and bone remodeling are key steps during bone healing, during which the cross-talk between mesenchymal stem cells (MSCs) and endothelial cells plays vital roles. Evidence indicates the well-characterized neuropeptide Calcitonin Gene-Related Peptide-α (CGRP) is proven to play an important role during bone regeneration. However, the regulatory effects of αCGRP on angiogenesis and osteogenesis, as well as underlying cellular and molecular mechanisms, remain unclear. Aim. The present study was performed to verify the availability of the CGRP for osteogenic capacity in MSCs and explore its potential underlying molecular mechanism. After that, the promoted angiogenic effect of CGRP as well as its underlying mechanisms was studied. Methods and Results. The results showed that CGRP could significantly increase the cyclic adenosine monophosphate (cAMP) level and promote the osteogenesis ability of MSCs via cAMP/PKA signaling pathway. Direct exposure to CGRP increased nitric oxide synthase expression, the release of NO, tube formation, and wound healing of human umbilical vein endothelial cells (HUVEC). The CGRP-treated MSCs were observed with high expression levels of angiogenic factors, such as bFGF and VEGF-α; the conditioned medium derived from CGRP-treated MSCs was also able to promote tube formation and transmembrane migration of HUVECs. Conclusion. These findings demonstrate the coregulated angiogenesis and osteogenesis effects of CGRP, especially for its regulation effects on the cross-talk between mesenchymal stem cells and endothelial cells.

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Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects

Mota,

LoGerfo,

Veves

et al. 2024

Contemporary Diabetes

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Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice

Cited by 5 publications

References 44 publications

The Vascular-Dependent and -Independent Actions of Calcitonin Gene-Related Peptide in Cardiovascular Disease

The Vascular-Dependent and -Independent Actions of Calcitonin Gene-Related Peptide in Cardiovascular Disease

Neural Peptide α-CGRP Coregulated Angiogenesis and Osteogenesis via Promoting the Cross-Talk between Mesenchymal Stem Cells and Endothelial Cells

Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects

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