Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel

Abstract

Alpha-calcitonin gene-related peptide dose dependently impaired angiotensin II-mediated vasoconstriction in human radial arteries, independent of nitric oxide and all potassium channels except the barium-sensitive Kir channel. Thus, calcitonin gene-related peptide is an endogenous inhibitor of angiotensin II-mediated vasoconstriction in the human radial artery.

Reduction of angiotensin A and alamandine vasoactivity in the rabbit model of atherogenesis: differential effects of alamandine and Ang(1‐7)

“…In the abdominal aorta, Ang(1‐7) or alamandine was added to the organ bath (10 −6 M), and 20 min later, an AngII or AngA concentration curve was performed (Zulli et al . ) (10 −9 –10 −6 M, half log units). In thoracic aorta and all other arteries, rings were precontracted to 50–80% of maximum (as determined by 124 mM K + response) with phenylephrine (10 −6 –10 −5 M).…”

Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels

“…Rabbits were used to assess the mechanism of AT1 receptor blockade due to their sensitivity to ANGII blood vessel constriction similar to human arteries [45,46]. Rabbits were killed by exsanguination after anesthesia with 4 % isoflurane, followed by the extraction of interlobar arteries from kidneys (VUAEC#03/11).…”