Calcitonin gene-related peptide is potential therapeutic target of osteoporosis

Wang, Hua; Lin, Xiaoxi; Liu, Yu; Wang, Jing

doi:10.1016/j.heliyon.2022.e12288

Cited by 6 publications

(2 citation statements)

References 71 publications

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“…Thus, neuropeptides, such as neuropeptide Y (NPY), substance P, or calcitonin gene-related peptide (CGRP) released locally [73][74][75], could influence the metabolic activity of bone cells (i.e., osteoblasts, osteoclasts, osteocytes) [76][77][78][79]. Neuropeptides, such as CGRP, may have a role to play in bone remodeling [80], in the treatment of osteoporosis [81] or in fracture healing [82]. Such neuro regulation could occur in collaboration with mechanical loading [83] or energy utilization during different stages of growth and aging [84].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Bone by Mechanical Loading, Sex Hormones, and Nerves: Integration of Such Regulatory Complexity and Implications for Bone Loss during Space Flight and Post-Menopausal Osteoporosis

Hart

2023

Biomolecules

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During evolution, the development of bone was critical for many species to thrive and function in the boundary conditions of Earth. Furthermore, bone also became a storehouse for calcium that could be mobilized for reproductive purposes in mammals and other species. The critical nature of bone for both function and reproductive needs during evolution in the context of the boundary conditions of Earth has led to complex regulatory mechanisms that require integration for optimization of this tissue across the lifespan. Three important regulatory variables include mechanical loading, sex hormones, and innervation/neuroregulation. The importance of mechanical loading has been the target of much research as bone appears to subscribe to the “use it or lose it” paradigm. Furthermore, because of the importance of post-menopausal osteoporosis in the risk for fractures and loss of function, this aspect of bone regulation has also focused research on sex differences in bone regulation. The advent of space flight and exposure to microgravity has also led to renewed interest in this unique environment, which could not have been anticipated by evolution, to expose new insights into bone regulation. Finally, a body of evidence has also emerged indicating that the neuroregulation of bone is also central to maintaining function. However, there is still more that is needed to understand regarding how such variables are integrated across the lifespan to maintain function, particularly in a species that walks upright. This review will attempt to discuss these regulatory elements for bone integrity and propose how further study is needed to delineate the details to better understand how to improve treatments for those at risk for loss of bone integrity, such as in the post-menopausal state or during prolonged space flight.

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Section: Introductionmentioning

confidence: 99%

Regulation of Bone by Mechanical Loading, Sex Hormones, and Nerves: Integration of Such Regulatory Complexity and Implications for Bone Loss during Space Flight and Post-Menopausal Osteoporosis

Hart

2023

Biomolecules

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“…Both SP and CGRP are also involved in bone metabolism as well. 33 , 34 Pain and QoL may be measured by different self-assessment tools. 30 , 35 , 36 …”

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confidence: 99%

The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial

Uzunel,

Kronhed,

Alin

et al. 2023

Archives of Rehabilitation Research and Clinical Translation

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Bone‐Targeted Delivery of Cell‐Penetrating‐RUNX2 Fusion Protein in Osteoporosis Model

et al. 2023

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The onset of osteoporosis leads to a gradual decrease in bone density due to an imbalance between bone formation and resorption. To achieve optimal drug efficacy with minimal side effects, targeted drug delivery to the bone is necessary. Previous studies have utilized peptides that bind to hydroxyapatite, a mineral component of bone, for bone‐targeted drug delivery. In this study, a hydroxyapatite binding (HAB) tag is fused to 30Kc19α‐Runt‐related transcription factor 2 (RUNX2) for bone‐targeting. This recombinant protein can penetrate the nucleus of human mesenchymal stem cells (hMSCs) and act as a master transcription factor for osteogenesis. The HAB tag increases the binding affinity of 30Kc19α‐RUNX2 to mineral deposition in mature osteoblasts and bone tissue, without affecting its osteogenic induction capability. In the osteoporosis mouse model, intravenous injection of HAB‐30Kc19α‐RUNX2 results in preferential accumulation in the femur and promotes bone formation while reducing toxicity in the spleen. These findings suggest that HAB‐30Kc19α‐RUNX2 may be a promising candidate for bone‐targeted therapy in osteoporosis.

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Calcitonin gene-related peptide is potential therapeutic target of osteoporosis

Cited by 6 publications

References 71 publications

Regulation of Bone by Mechanical Loading, Sex Hormones, and Nerves: Integration of Such Regulatory Complexity and Implications for Bone Loss during Space Flight and Post-Menopausal Osteoporosis

Regulation of Bone by Mechanical Loading, Sex Hormones, and Nerves: Integration of Such Regulatory Complexity and Implications for Bone Loss during Space Flight and Post-Menopausal Osteoporosis

The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial

Bone‐Targeted Delivery of Cell‐Penetrating‐RUNX2 Fusion Protein in Osteoporosis Model

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