Calcitonin gene-related peptide-like immunoreactive sensory fibers form synaptic contact with sympathetic neurons in the rat celiac ganglion

Lee, Yasuhide; Hayashi, Norio; Hillyard, C. J.; Girgis, S. I.; MacIntyre, I.; Emson, Piers C.; Tohyama, Masaya

doi:10.1016/0006-8993(87)91229-7

Cited by 43 publications

(9 citation statements)

References 7 publications

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“…In addition to preganglionic and intestinofugal inputs, PVG receive collateral projections from unmyelinated sensory neurons containing SP (Kondo and Yui, 1981;Matthews and Cuello, 1984;Masuko and Chiba, 1988) and CGRP (Lee et al, 1987;Lindh et al, 1988). We have observed a sparse innervation of PVG by SP-IR fibers which could be collaterals of spinal afferents.…”

Section: Immunohistochemistrymentioning

confidence: 79%

“…These afferent fibers complete the sympathetic reflex arc by activating the preganglionic sympathetic neurons of the intermediolateral cell column (IML). The same sensory fibers project collateral fibers to the sympathetic motoneurons located in the PVG (Matthews and Cuello, 1982;Lee et al, 1987). The afferent component of entero-enteric inhibitory reflexes is carried by the intestinofugal neurons (IFANs), which send axons from the enteric nervous system (ENS) outside the GIT to the PVG (Szurszewski, 1981;Furness, 2003Furness, , 2006a.…”

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confidence: 99%

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Sympathetic innervation of the ileocecal junction in horses

Russo

Bombardi

Grandis

et al. 2010

J of Comparative Neurology

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The distribution and chemical phenotypes of sympathetic and dorsal root ganglion (DRG) neurons innervating the equine ileocecal junction (ICJ) were studied by combining retrograde tracing and immunohistochemistry. Immunoreactivity (IR) for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), neuronal nitric oxide synthase (nNOS), calcitonin gene-related peptide (CGRP), substance P (SP), and neuropeptide Y (NPY) was investigated. Sympathetic neurons projecting to the ICJ were distributed within the celiac (CG), cranial mesenteric (CranMG), and caudal mesenteric (CaudMG) ganglia, as well as in the last ganglia of the thoracic sympathetic chain and in the splanchnic ganglia. In the CG and CranMG 91 +/- 8% and 93 +/- 12% of the neurons innervating the ICJ expressed TH- and DBH-IR, respectively. In the CaudMG 90 +/- 15% and 94 +/- 5% of ICJ innervating neurons were TH- and DBH-IR, respectively. Sympathetic (TH-IR) fibers innervated the myenteric and submucosal ganglia, ileal blood vessels, and the muscle layers. They were more concentrated at the ICJ level and were also seen encircling myenteric plexus (MP) and submucosal plexus (SMP) descending neurons that were retrogradely labeled from the ICJ. Among the few retrogradely labeled DRG neurons, nNOS-, CGRP-, and SP-IR nerve cells were observed. Dense networks of CGRP-, nNOS-, and SP-IR varicosities were seen around retrogradely labeled prevertebral ganglia neurons. The CGRP-IR fibers are probably the endings of neurons projecting from the intestine to the prevertebral ganglia. These findings indicate that this crucial region of the intestinal tract is strongly influenced by the sympathetic system and that sensory information of visceral origin influences the sympathetic control of the ICJ.

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Section: Immunohistochemistrymentioning

confidence: 79%

mentioning

confidence: 99%

Sympathetic innervation of the ileocecal junction in horses

Russo

Bombardi

Grandis

et al. 2010

J of Comparative Neurology

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“…Islet‐innervating nerve fibers could originate from the intrapancreatic, celiac, nodose or dorsal root ganglia (Sharkey et al ., 1984; Su et al ., 1987; Neuhuber, 1989; Won et al ., 1998; Ahrén, 2000). While neither the intrapancreatic nor the celiac ganglia contain CGRP‐expressing perikarya in the rat (Lee et al ., 1987; Sternini et al ., 1992), a substantial proportion of both nodose ganglion and DRG neurons express this neuropeptide (Helke & Hill, 1988; Silverman & Kruger, 1988). However, as nodose ganglia provide very little innervation to the islets (Neuhuber, 1989), the great majority of the CGRP‐ and TRPV1‐coexpressing fibers in the islets must be of DRG origin.…”

Section: Discussionmentioning

confidence: 99%

Capsaicin‐sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes

Gram

Åhrén

Nagy

et al. 2007

Eur J of Neuroscience

143

122

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The system that regulates insulin secretion from beta-cells in the islet of Langerhans has a capsaicin-sensitive inhibitory component. As calcitonin gene-related peptide (CGRP)-expressing primary sensory fibers innervate the islets, and a major proportion of the CGRP-containing primary sensory neurons is sensitive to capsaicin, the islet-innervating sensory fibers may represent the capsaicin-sensitive inhibitory component. Here, we examined the expression of the capsaicin receptor, vanilloid type 1 transient receptor potential receptor (TRPV1) in CGRP-expressing fibers in the pancreatic islets, and the effect of selective elimination of capsaicin-sensitive primary afferents on the decline of glucose homeostasis and insulin secretion in Zucker diabetic fatty (ZDF) rats, which are used to study various aspects of human type 2 diabetes mellitus. We found that CGRP-expressing fibers in the pancreatic islets also express TRPV1. Furthermore, we also found that systemic capsaicin application before the development of hyperglycemia prevents the increase of fasting, non-fasting, and mean 24-h plasma glucose levels, and the deterioration of glucose tolerance assessed on the fifth week following the injection. These effects were accompanied by enhanced insulin secretion and a virtually complete loss of CGRP- and TRPV1-coexpressing islet-innervating fibers. These data indicate that CGRP-containing fibers in the islets are capsaicin sensitive, and that elimination of these fibers contributes to the prevention of the deterioration of glucose homeostasis through increased insulin secretion in ZDF rats. Based on these data we propose that the activity of islet-innervating capsaicin-sensitive fibers may have a role in the development of reduced insulin secretion in human type 2 diabetes mellitus.

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“…In contrast, SP is found only in unmyelinated (50%) and thinly myelinated (20%) fibres (McCarthy and Lawson 1989). On their way to the gastrointestinal tract, the fibres of spinal afferent neurons pass through the prevertebral ganglia (Dalsgaard et Matthews and Cuello 1984;Y. Lee et al 1987a;Suet al 1987; Green and Dockray 1988;Lindh et al 1988;Kashiba et al 1990) where they give of collaterals that form axodendritic and axosomatic synapses with the principal sympathetic ganglion cells (Kondo and Yui 1981;M.R.…”

Section: Innervation Of the Splanchnic Vascular Bed By Peptidergic Afmentioning

confidence: 99%

Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds

Holzer

Reviews of Physiology, Biochemistry and Pharmacology

201

122

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Calcitonin gene-related peptide-like immunoreactive sensory fibers form synaptic contact with sympathetic neurons in the rat celiac ganglion

Cited by 43 publications

References 7 publications

Sympathetic innervation of the ileocecal junction in horses

Sympathetic innervation of the ileocecal junction in horses

Capsaicin‐sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes

Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds

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