Calcitonin gene-related peptide produces skeletal muscle vasodilation following antidromic stimulation of unmyelinated afferents in the dorsal root in rats

Sato, Akio; Sato, Yuko; Shimura, Mayura; Uchida, Sae

doi:10.1016/s0304-3940(00)00932-0

Cited by 105 publications

(82 citation statements)

References 12 publications

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“…sympathetic) and median nerve conduction response to acupuncture in CTS patients. Another mechanism by which acupuncture, particularly local acupuncture, modulates median nerve vasa nervorum blood flow may be via antidromic vasodilation following stimulation of spinal dorsal roots-an effect mediated by calcitonin gene-related peptide (Sato et al, 1994(Sato et al, , 2000. Ultrasound studies have explored median nerve hypervascularity (Ghasemi-Esfe et al, 2011;Ooi et al, 2014), a compensatory response to ischaemia within the tunnel, and future studies should link median nerve vascularity with neuroplasticity response to acupuncture therapy.…”

Section: Discussionmentioning

confidence: 99%

Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture

Maeda

Kim

Kettner

et al. 2017

Brain

134

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Ã These authors contributed equally to this work.Carpal tunnel syndrome is the most common entrapment neuropathy, affecting the median nerve at the wrist. Acupuncture is a minimally-invasive and conservative therapeutic option, and while rooted in a complex practice ritual, acupuncture overlaps significantly with many conventional peripherally-focused neuromodulatory therapies. However, the neurophysiological mechanisms by which acupuncture impacts accepted subjective/psychological and objective/physiological outcomes are not well understood. Eligible patients (n = 80, 65 female, age: 49.3 AE 8.6 years) were enrolled and randomized into three intervention arms: (i) verum electro-acupuncture 'local' to the more affected hand; (ii) verum electro-acupuncture at 'distal' body sites, near the ankle contralesional to the more affected hand; and (iii) local sham electro-acupuncture using non-penetrating placebo needles. Acupuncture therapy was provided for 16 sessions over 8 weeks. Boston Carpal Tunnel Syndrome Questionnaire assessed pain and paraesthesia symptoms at baseline, following therapy and at 3-month follow-up. Nerve conduction studies assessing median nerve sensory latency and brain imaging data were acquired at baseline and following therapy. Functional magnetic resonance imaging assessed somatotopy in the primary somatosensory cortex using vibrotactile stimulation over three digits (2, 3 and 5). While all three acupuncture interventions reduced symptom severity, verum (local and distal) acupuncture was superior to sham in producing improvements in neurophysiological outcomes, both local to the wrist (i.e. median sensory nerve conduction latency) and in the brain (i.e. digit 2/3 cortical separation distance). Moreover, greater improvement in second/third interdigit cortical separation distance following verum acupuncture predicted sustained improvements in symptom severity at 3-month follow-up. We further explored potential differential mechanisms of local versus distal acupuncture using diffusion tensor imaging of white matter microstructure adjacent to the primary somatosensory cortex. Compared to healthy adults (n = 34, 28 female, 49.7 AE 9.9 years old), patients with carpal tunnel syndrome demonstrated increased fractional anisotropy in several regions and, for these regions we found that improvement in median nerve latency was associated with reduction of fractional anisotropy near (i) contralesional hand area following verum, but not sham, acupuncture; (ii) ipsilesional hand area following local, but not distal or sham, acupuncture; and (iii) ipsilesional leg area following distal, but not local or sham, acupuncture. As these primary somatosensory cortex subregions are distinctly targeted by local versus distal acupuncture electrostimulation, acupuncture at local versus distal sites may improve median nerve function at the wrist by somatotopically distinct neuroplasticity in the primary somatosensory cortex following therapy. Our study further suggests that improvements in primary somatosensory cortex ...

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Section: Discussionmentioning

confidence: 99%

Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture

Maeda

Kim

Kettner

et al. 2017

Brain

134

View full text Add to dashboard Cite

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“…Tsuru also examined the effects of MA on blood flow in rats in various tissues, including muscle, using colored microspheres, and he found increases of MBF at the needling points (71). Sato et al, using a laser Doppler flowmeter, found that repetitive antidromic electrical stimulation of unmyelinated C fibers in dorsal roots increased the ipsilateral biceps femoral MBF in rats, and they determined that the increase in MBF was independent of the mean arterial blood pressure (MAP) (72). These facts suggest that the increase in MBF caused by MA is mediated mainly by an axon reflex in the muscle.…”

Section: Effects Of Acupuncture On Circulation In Musclementioning

confidence: 99%

How Do Acupuncture and Moxibustion Act? – Focusing on the Progress in Japanese Acupuncture Research –

et al. 2006

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Abstract. The mechanisms of action of acupuncture and moxibustion as reported by Japanese researchers are reviewed. The endogenous opioid-mediated mechanisms of electroacupuncture (EA) as used in China are well understood, but these are only one component of all mechanisms of acupuncture. These studies emphasize the similarity of the analgesic action of EA to various sensory inputs to the pain inhibition mechanisms. In Japanese acupuncture therapy, careful detection of the acupuncture points and fine needling technique with comfortable subjective sensation are considered important. The role of polymodal receptors (PMR) has been stressed based on the facts that PMRs are responsive to both acupuncture and moxibustion stimuli, thermal sensitivity is essential in moxibustion therapy, and the characteristics of acupuncture points and trigger points are similar to those of sensitized PMRs. Acupuncture and moxibustion are also known to affect neurons in the brain reward systems and blood flow in skin, muscle, and nerve. Axon reflexes mediated by PMRs might be a possible mechanism for the immediate action of acupuncture and moxibustion. Reports on the curative effects of acupuncture on various digestive and urological disorders are also reviewed briefly.

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“…Akupunktura wpływa też na aktywność serotoniny i noradrenaliny w ośrodkowym układzie nerwowym [48,49], mogąc stabilizować ośrodek termoregulacji [50]. Działa również obwodowo poprzez zwiększone wydzielanie substancji P, wazoaktywnego peptydu jelitowego (vasoactive intestinal peptide -VIP) oraz peptydu spokrewnionego z genem kalcytoniny CGRP [51]. W 1997 r. opublikowano stanowisko Narodowego Instytutu Zdrowia (NIH) w Stanach Zjednoczonych w sprawie akupunktury, w którym zaznaczono, że w wielu jednostkach chorobowych: […] akupunktura może być przydatna jako leczenie wspomagające lub akceptowana alternatywa, bądź może być częścią całościowego planu leczenia.…”

Section: Wstępunclassified

Is acupuncture effective in treatment of hot flashes?

Woźniak¹,

Ziółkowski²,

Stetkiewicz³

et al. 2012

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StreszczenieMenopauza jest kolejnym etapem życia kobiety, w którym bardzo często dochodzi do obniżenia jakości życia ze względu na występowanie wielu schorzeń i objawów, m.in. objawów wypadowych typu uderzenia gorąca. Uderzenia gorąca i nadmierne pocenie się, będące ich nocnym odpowiednikiem, występują w okresie okołome-nopauzalnym u większości kobiet. Jednocześnie są najczęstszym powodem zgłaszania się pacjentek w okresie okołomenopauzalnym do ginekologa. Podstawowym sposobem terapii tych zaburzeń jest stosowanie menopauzalnej terapii hormonalnej (menopausal hormone therapy -MHT).Jednak nie wszystkie kobiety mogą stosować MHT, a część z nich dodatkowo obawia się terapii hormonalnej. Ta grupa pacjentek szuka alternatywnego sposobu złagodzenia objawów klimakterycznych. Jedną z tych metod jest akupunktura, która w ostatnim dziesięcioleciu znalazła uznanie jako metoda bezpieczna i skuteczna. Autorzy przeprowadzili retrospektywne badanie grupy 86 pacjentek w okresie okołomenopauzalnym, niestosujących MHT, z nasilonymi objawami naczynioruchowymi, które poddały się w latach 2010-2011 zabiegom akupunktury. Badanie to miało odpowiedzieć na pytanie o skuteczność akupunktury w leczeniu uderzeń gorąca.Słowa kluczowe: akupunktura, menopauza, uderzenia gorąca. SummaryThe menopause is a successive stage of the woman's life, during which the quality of her life decreases very frequently due to the occurrence of many diseases and symptoms, among others, the perimenopausal symptoms such as hot flashes. Hot flashes and hidrosis as their night equivalent, appear during the perimenopausal period in the majority of women. At the same time, they are the most frequent reason of women patients in the perimenopausal period, for seeing the gynaecologist. The basic therapeutic method used in treatment of the above mentioned disorders is the menopausal hormone therapy (MHT).Nevertheless, not every woman can apply the MHT, and some women are also afraid of using any hormone therapy. Namely, this group of women is looking for an alternative way to relieve symptoms of the climacteric. One of these methods is acupuncture, which gained a recognition within the last decade as a safe and effective method. The authors conducted a retrospective study with a group of 86 women patients in the perimenopausal period with the exacerbated vasomotor symptoms, who were not applying any MHT, but who underwent acupuncture treatment in 2010-2011. The study was to answer a question about effectiveness of acupuncture in treatment of hot flashes.

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Calcitonin gene-related peptide produces skeletal muscle vasodilation following antidromic stimulation of unmyelinated afferents in the dorsal root in rats

Cited by 105 publications

References 12 publications

Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture

Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture

How Do Acupuncture and Moxibustion Act? – Focusing on the Progress in Japanese Acupuncture Research –

Is acupuncture effective in treatment of hot flashes?

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