2021
DOI: 10.1530/ec-21-0071
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Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis

Abstract: Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the … Show more

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Cited by 6 publications
(4 citation statements)
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“…In blood tests, Pro-GRP, which is specific for SCLC, is reported to be high, especially in nongastrointestinal neuroendocrine carcinoma, and may also be elevated in LCNEC of the lung, as seen in this case (10). In addition, calcitonin, a hormone specific to the thyroid gland, may be elevated in lung neuroendocrine tumors, as seen in this case (11).…”
Section: A B C D E F G H Imentioning
confidence: 67%
“…In blood tests, Pro-GRP, which is specific for SCLC, is reported to be high, especially in nongastrointestinal neuroendocrine carcinoma, and may also be elevated in LCNEC of the lung, as seen in this case (10). In addition, calcitonin, a hormone specific to the thyroid gland, may be elevated in lung neuroendocrine tumors, as seen in this case (11).…”
Section: A B C D E F G H Imentioning
confidence: 67%
“…NEN-UPs derived from the bronchi or lungs are usually positive for classic neuroendocrine markers and often express TTF1 and bombesin/gastrin-releasing peptide (GRP) [30]. Subsets of cases may also express calcitonin or calcitonin-related peptide [46]. However, note that subsets of typical and atypical carcinoids may display aberrant expression of serotonin, while pulmonary NECs may upregulate PAX8 (Figure 4) [47,48].…”
Section: Metastatic Pulmonary Nenmentioning
confidence: 99%
“…The neuroendocrine cells of the stomach and lung, and the parafollicular cells (C cells) of the thyroid, secrete procalcitonin (PCT), a 116-amino acid peptide precursor of calcitonin. Pantzaris et al [4], under the regulation of the CALC-1 gene [5]. In healthy individuals serum PCT levels stay below the detection limit of 0.01 microg/l [6].…”
Section: Introductionmentioning
confidence: 99%